Evidence map›Paper›PMID 34249330›Full record

ArticlePulmonary circulation

Pulmonary arterial hypertension patients display normal kinetics of clot formation using thrombelastography.

Mengyun Lu, Kevin P Blaine, Ann Cullinane, Courtney Hall, Alina Dulau-Florea, Junfeng Sun, Herman F Chenwi, Grace M Graninger, Bonnie Harper, Keshia Thompson and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pulmonary circulation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Mengyun LuCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0002-1823-9103
Kevin P BlaineCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Ann CullinaneDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Courtney HallDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Alina Dulau-FloreaDepartment of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Junfeng SunCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Herman F ChenwiCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Grace M GraningerCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Bonnie HarperCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Keshia ThompsonCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Janell KrackPharmacy Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Christopher F BarnettMedStar Heart and Vascular Institute, MedStar Washington Hospital Center, Washington, DC, USA.
Samuel B BruscaCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0003-3762-7918
Jason M ElinoffCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.
Michael A SolomonCritical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, MD, USA.ORCID https://orcid.org/0000-0001-7400-6614
National Institutes of Health Clinical Center · USMedStar Washington Hospital Center · USNational Institutes of Health · USUniversity of Southern California · US

Funding

Obtaining Samples from Human Subjects to Facilitate Basic, Translational and Clinical ResearchZIACL009029 · CLC · CLINICAL CENTER · PI SOLOMON, MICHAEL · 2018 to 2025
$0k
Clinical Translational Research Program in Pulmonary Arterial Hypertension (PAH): Disease Mechanisms, Biomarkers, and Novel Therapeutic TargetsZIACL090066 · CLC · CLINICAL CENTER · PI SOLOMON, MICHAEL · 2020 to 2025
$0k
6 · The paper itself

Abstract

Pulmonary arterial hypertension is characterized by endothelial dysfunction and microthrombi formation. The role of anticoagulation remains controversial, with studies demonstrating inconsistent effects on pulmonary arterial hypertension mortality. Clinical anticoagulation practices are currently heterogeneous, reflecting physician preference. This study uses thrombelastography and hematology markers to evaluate whether clot formation and fibrinolysis are abnormal in pulmonary arterial hypertension patients. Venous blood was collected from healthy volunteers (

Indexed as

anticoagulationfibrinolysisthrombosis

Identifiers

PMID34249330
PMCPMC8237222
OpenAlexW3165143605

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.