SynthesisFrontline gastroenterology2021
Gastrointestinal manifestations of COVID-19 in children: a systematic review and meta-analysis.
Synthesis in Frontline gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- European Society for Paediatric Gastroenterology, Hepatology and Nutrition/North American Society for Pediatric Gastroenterology, Hepatology and Nutrition guidelines for treatment of functional constipation in children aged 0-18 years.Journal of pediatric gastroenterology and nutrition · 2026Guideline
- Evidence linking COVID-19 and the health/well-being of children and adolescents: an umbrella review.BMC medicine · 2024Pooled it
- Association Between Congenital Gastrointestinal Malformation Outcome and Largely Asymptomatic SARS-CoV-2 Infection in Pediatric Patients-A Systematic Review.Journal of clinical medicine · 2025Review
- The Relationship between Liver Enzyme Levels and Severity of Lung Involvement in Children with COVID-19 Infection.Medical journal of the Islamic Republic of Iran · 2025Article
- Surgical aspects of pediatric abdominal pain in the era of COVID-19: clinical consideration and outcomes.Frontiers in pediatrics · 2024Article
- Gastrointestinal and Hepatic Manifestations of COVID-19 in Children: A Systematic Review and Meta-analysis.Acta medica Philippina · 2024Article
- COVID 19 infection clinical features in pediatric patients in Southwestern Iran: a cross-sectional, multi-center study.BMC infectious diseases · 2023Article
- Article
- Hangover-Related Internet Searches Before and During the COVID-19 Pandemic in England: Observational Study.JMIR formative research · 2023Article
- Review
- SARS-CoV-2 Antibodies in Children with Chronic Disease from a Pediatric Gastroenterology Outpatient Clinic.Pediatric gastroenterology, hepatology & nutrition · 2022Article
- Article
- COVID-19 in Portugal: a retrospective review of paediatric cases, hospital and PICU admissions in the first pandemic year.BMJ paediatrics open · 2022Article
- Adenomesenteritis following SARS-CoV-2 Vaccination in Children: A Case Report and Review of The Literature.Children (Basel, Switzerland) · 2022Article
- Isolated rhinorrhea in the presentation of SARS-CoV-2 infection among preschool- versus school-aged children.Paediatrics & child health · 2022Article
- Ileocolic intussusception in pediatric SARS-CoV-2 patients: experience at a tertiary pediatric center.Pediatric surgery international · 2022Article
- Acute appendicitis and SARS-CoV-2 in children: imaging findings at a tertiary children's hospital during the COVID-19 pandemic.Pediatric radiology · 2022Article
- Limited Additive Diagnostic Impact of Isolated Gastrointestinal Involvement for the Triage of Children with Suspected COVID-19.Children (Basel, Switzerland) · 2022Article
- COVID-19 and vertical transmission: assessing the expression of ACE2/TMPRSS2 in the human fetus and placenta to assess the risk of SARS-CoV-2 infection.BJOG : an international journal of obstetrics and gynaecology · 2022Article
- COVID-19 in a group of children with asthma: presentation, severity, and outcome.American journal of clinical and experimental immunology · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo summarise the published evidence on the gastrointestinal manifestations of COVID-19 in children and to determine the prevalence of gastrointestinal symptoms.
methodsIn this systematic review and meta-analysis, we searched PubMed, Embase, CINAHL and the WHO's database of publications on novel coronavirus. We included English language studies that had described original demographic and clinical characteristics of children diagnosed with COVID-19 and reported on the presence or absence of gastrointestinal symptoms. Meta-analysis was conducted using the random-effects model. The pooled prevalence of gastrointestinal symptoms was expressed as proportion and 95% CI.
resultsThe search identified 269 citations. Thirteen studies (nine case series and four case reports) comprising data for 284 patients were included. Overall, we rated four studies as having a low risk of bias, eight studies as moderate and one study as high risk of bias. In a meta-analysis of nine studies, comprising 280 patients, the pooled prevalence of all gastrointestinal symptoms was 22.8% (95% CI 13.1% to 35.2%; I
conclusionsNearly a quarter of children with COVID-19 have gastrointestinal symptoms. It is important for clinicians to be aware of the gastrointestinal manifestation of COVID-19. PROSPERO REGISTRATION NUMBER: CRD42020177569.
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