Evidence map›Paper›PMID 34249318›Full record

ReviewFrontline gastroenterology2021

Recent advances in the detection and management of early gastric cancer and its precursors.

William Waddingham, Stella A V Nieuwenburg, Sean Carlson, Manuel Rodriguez-Justo, Manon Spaander, Ernst J Kuipers, Marnix Jansen, David G Graham, Matthew Banks

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontline gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 2 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 2 syntheses or guidelines pooled it, 76 citations in OpenAlex.

  1. Pooled it
  2. Diagnostic performance of blue laser imaging for early detection of gastric cancer: A systematic review and meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2024
    Pooled it
  3. Review
  4. Article
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  6. Multi-modal monocular endoscopic depth and pose estimation with edge-guided self-supervision.International journal of computer assisted radiology and surgery · 2026
    Article
  7. Article
  8. Article
  9. Article
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  11. Article
  12. Article
  13. Nomogram Prediction for Gastric Cancer Development.Clinical and translational gastroenterology · 2025
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

William Waddingham *Gastroenterology, University College London Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0002-9440-8810
Stella A V Nieuwenburg *Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Sean CarlsonGastroenterology, University College London Hospitals NHS Foundation Trust, London, UK.
Manuel Rodriguez-JustoPathology, University College London Hospitals NHS Foundation Trust, London, UK.
Manon SpaanderGastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Ernst J KuipersGastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Marnix JansenResearch Department of Pathology, UCL Cancer Institute, London, UK.
David G GrahamGastroenterology, University College London Hospitals NHS Foundation Trust, London, UK.
Matthew BanksGastroenterology, University College London Hospitals NHS Foundation Trust, London, UK.ORCID 0000-0002-9137-2779
University College London Hospitals NHS Foundation Trust · GBErasmus MC · NL

Funding

Medical Research Council MR/S022244/1
6 · The paper itself

Abstract

Despite declines in incidence, gastric cancer remains a disease with a poor prognosis and limited treatment options due to its often late stage of diagnosis. In contrast, early gastric cancer has a good to excellent prognosis, with 5-year survival rates as high as 92.6% after endoscopic resection. There remains an East-West divide for this disease, with high incidence countries such as Japan seeing earlier diagnoses and reduced mortality, in part thanks to the success of a national screening programme. With missed cancers still prevalent at upper endoscopy in the West, and variable approaches to assessment of the high-risk stomach, the quality of endoscopy we provide must be a focus for improvement, with particular attention paid to the minority of patients at increased cancer risk. High-definition endoscopy with virtual chromoendoscopy is superior to white light endoscopy alone. These enhanced imaging modalities allow the experienced endoscopist to accurately and robustly detect high-risk lesions in the stomach. An endoscopy-led staging strategy would mean biopsies could be targeted to histologically confirm the endoscopic impression of premalignant lesions including atrophic gastritis, gastric intestinal metaplasia, dysplasia and early cancer. This approach to quality improvement will reduce missed diagnoses and, combined with the latest endoscopic resection techniques performed at expert centres, will improve early detection and ultimately patient outcomes. In this review, we outline the latest evidence relating to diagnosis, staging and treatment of early gastric cancer and its precursor lesions.

Indexed as

gastric adenocarcinomagastric inflammationgastric metaplasiagastrointesinal endoscopyHelicobacter pylori - gastritis

Identifiers

PMID34249318
PMCPMC8223672
OpenAlexW3046273161

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.