Evidence map›Paper›PMID 34249286›Full record

ArticleInternational journal of preventive medicine2021

Significance of Serum Protein Electrophoresis in the Detection of Multiple Myeloma: A Diagnostic Interpretation of Patients with Varied Immunoglobulins.

B S Nayak, Nikkisha Ojar-Taylor, Samara St John, Shanygne Swann, Jayselle Thom, Brandon Thomas, Lisa Thomas, Daniella Townsend, Shaquille Trotman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of preventive medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Review
  3. Thrombotic Risk and Calculated Whole Blood Viscosity in a Cohort of Patients With New Diagnosis of Multiple Myeloma.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

B S NayakDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical Sciences, Trinidad.
Nikkisha Ojar-TaylorDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical Sciences, Trinidad.
Samara St JohnDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical Sciences, Trinidad.
Shanygne SwannDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical Sciences, Trinidad.
Jayselle ThomDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical Sciences, Trinidad.
Brandon ThomasDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical Sciences, Trinidad.
Lisa ThomasDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical Sciences, Trinidad.
Daniella TownsendDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical Sciences, Trinidad.
Shaquille TrotmanDepartment of Preclinical Sciences, The University of the West Indies, Faculty of Medical Sciences, Trinidad.
University of the West Indies System · JM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo determine the relationship between serum protein electrophoresis (SPE) and serum immunoglobulin profiles of patients with multiple myeloma (MM).

methodsThis is a retrospective study conducted at the Eric Williams Medical Sciences Complex, focusing on patients over 18 years who received diagnostic blood tests for MM. Results for SPE and serum immunoglobulin profiles were obtained using lab logbooks. Descriptive and inferential statistics techniques were used to analyze the data.

resultsThe median age of MM patients in Trinidad and Tobago is of 69 years. The ratio of male and female patients with the MM is 50:50. Out of 131 patients, 24 (18.32%) had M bands present, 60 (45.80%) had an increase in gamma globulin, and 16 (12.21%) had a decrease in albumin. In cases of M band presence and raised gamma, there was noticeable increase in IgG concentration and a slight increase in IgM concentration. There was also an increase in IgA concentration in patients with the M-band but a decrease in concentration in those with raised gamma. Patients with an elevated gamma had a significant increase in IgG diameter and IgG concentration.

conclusionsThis study showed a relationship between the presence of M bands and serum immunoglobulins. It has proven the significance of SPE and immunoglobulins, like IgG and IGM, in the detection of MM in the early and advanced stages. Therefore, it is recommended that SPE be used, along with other laboratory tests, in the diagnosis of MM.

Indexed as

Immunoglobulinsmultiple myelomaserum protein electrophoresis

Identifiers

PMID34249286
PMCPMC8218806
OpenAlexW3160330454

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.