ArticleIranian journal of basic medical sciences2021
Diabetes mellitus can cause cardiomyopathy disorders by inducing the aging pathway.
Article in Iranian journal of basic medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed, 4 citations in OpenAlex.
- Putative effect of melatonin on cardiomyocyte senescence in mice with type 1 diabetes mellitus.Journal of diabetes and metabolic disorders · 2022Article
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4 authors at 3 institutions in 1 country.
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Abstract
objectivesIn this study, cardiovascular disorders were examined with a focus on the aging pathway and autophagy involvement in cardiac samples isolated from male rats with type 2 diabetes mellitus. MATERIALS AND
methodsIn the present study, male Wistar rats became diabetic with the help of a high-fat diet. Gene and protein expression levels (to evaluate Tumor Necrosis Factor-α, TNF-α) were measured by the ELISA method. Nrf2, p38, and GSK-3β proteins in cardiac tissue samples were measured by the western blotting method. Autophagy examination was performed with immunofluorescence staining. Finally, quantitative results were calculated using statistical analysis.
resultsThe expression of beta-galactosidase genes had a significant increase in the diabetic group (
conclusionType 2 diabetes mellitus in rats will increase aging in cardiac cells. Examination of the signaling pathway indicates that this effect is related to the increase of ROS and the activity of the signaling pathway. In response, the cardiac cells try to maintain their homeostasis by increasing autophagy and decreasing inflammatory cytokines.
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