Evidence map›Paper›PMID 34249000›Full record

ArticleFrontiers in immunology2021

Plasma Extracellular Vesicles Enhance HIV-1 Infection of Activated CD4

Isobel Okoye, Lai Xu, Olaide Oyegbami, Shima Shahbaz, Desmond Pink, Priscilla Gao, Xuejun Sun, Shokrollah Elahi

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
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  16. MicroRNAs in T Cell-Immunotherapy.International journal of molecular sciences · 2022
    Review
  17. Article
  18. Review
  19. Regulatory Role of miRNAs and lncRNAs in Gout.Computational and mathematical methods in medicine · 2022
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Isobel OkoyeDivision of Foundational Sciences, School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Lai XuDivision of Foundational Sciences, School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Olaide OyegbamiDivision of Foundational Sciences, School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Shima ShahbazDivision of Foundational Sciences, School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
Desmond PinkDepartment of Oncology, Faculty of Medicine and Dentistry, Edmonton, AB, Canada.
Priscilla GaoDepartment of Oncology, Faculty of Medicine and Dentistry, Edmonton, AB, Canada.
Xuejun SunDepartment of Oncology, Faculty of Medicine and Dentistry, Edmonton, AB, Canada.
Shokrollah ElahiDivision of Foundational Sciences, School of Dentistry, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada.
University of Alberta · CA

Funding

CIHR
6 · The paper itself

Abstract

HIV latency is a challenge to the success of antiretroviral therapy (ART). Hence patients may benefit from interventions that efficiently reactivate the latent virus to be eliminated by ARTs. Here we show that plasma extracellular vesicles (pEVs) can enhance HIV infection of activated CD4

Indexed as

B7-H1 AntigenCase-Control StudiesCD4-Positive T-LymphocytesCell LineExtracellular VesiclesFemaleForkhead Box Protein O1Gene Expression RegulationHIV-1HIV InfectionsHumansJurkat CellsLymphocyte ActivationMaleMicroRNAsProgrammed Cell Death 1 ReceptorB7-H1 AntigenCD274 protein, humanForkhead Box Protein O1FOXO1 protein, humanMicroRNAsMIRN139 microRNA, humanPDCD1 protein, humanProgrammed Cell Death 1 ReceptorCD4+ T cellsextracellular vehicles (EVs)HIVHIV latencymicroRNAsPD-1/PD-L1T cell activation

Identifiers

PMID34249000
PMCPMC8264662
OpenAlexW3176233050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.