Evidence map›Paper›PMID 34248995›Full record

ArticleFrontiers in immunology2021

Case Report: Interleukin-2 Receptor Common Gamma Chain Defect Presented as a Hyper-IgE Syndrome.

Brahim Belaid, Lydia Lamara Mahammed, Aida Mohand Oussaid, Melanie Migaud, Yasmine Khadri, Jean Laurent Casanova, Anne Puel, Nafissa Ben Halla, Reda Djidjik

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Review
  3. A novel hypomorphic mutation inThe journal of allergy and clinical immunology. Global · 2025
    Article
  4. Article
  5. Review
  6. NovelCentral-European journal of immunology · 2024
    Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Brahim BelaidDepartment of Medical Immunology, Beni-Messous University Hospital Center, Algiers, Algeria.
Lydia Lamara MahammedDepartment of Medical Immunology, Beni-Messous University Hospital Center, Algiers, Algeria.
Aida Mohand OussaidFaculty of Medicine, Benyoucef Benkhedda University of Algiers 1, Algiers, Algeria.
Melanie MigaudLaboratory of Human Genetics of Infectious Diseases, Necker Hospital for Sick Children, INSERM UMR 1163, Paris, France.
Yasmine KhadriDepartment of Pediatrics A, Beni-Messous University Hospital Center, Algiers, Algeria.
Jean Laurent CasanovaLaboratory of Human Genetics of Infectious Diseases, Necker Hospital for Sick Children, INSERM UMR 1163, Paris, France.
Anne PuelLaboratory of Human Genetics of Infectious Diseases, Necker Hospital for Sick Children, INSERM UMR 1163, Paris, France.
Nafissa Ben HallaFaculty of Medicine, Benyoucef Benkhedda University of Algiers 1, Algiers, Algeria.
Reda DjidjikDepartment of Medical Immunology, Beni-Messous University Hospital Center, Algiers, Algeria.
University of Algiers Benyoucef Benkhedda · DZInserm · FRInstitut des Maladies Génétiques Imagine · FRUniversité Paris Cité · FR

Funding

Genome-wide search for inborn errors of IL-17 immunity underlying chronic mucocutaneous candidiasisR01AI127564 · NIAID · UT SOUTHWESTERN MEDICAL CENTER · PI Jean-Laurent Casanova · 2017 to 2026
$4.8M
Howard Hughes Medical InstituteNIAID NIH HHS R01 AI127564
6 · The paper itself

Abstract

X-linked severe combined immunodeficiency (X-SCID) is caused by mutations of

Indexed as

Mutation, MissenseCell ProliferationChildGenetic Predisposition to DiseaseHumansInterleukin Receptor Common gamma SubunitJob SyndromeLymphocyte ActivationMalePhenotypeT-Lymphocyte SubsetsX-Linked Combined Immunodeficiency DiseasesIL2RG protein, humanInterleukin Receptor Common gamma Subunitcombined immunodeficiencyhyper-IgEhypomorphic mutationsinborn error of immunityInterleukin-2 receptor gamma

Identifiers

PMID34248995
PMCPMC8264782
OpenAlexW3175680731

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.