ArticleFrontiers in immunology2021
Dietary Betaine Mitigates Hepatic Steatosis and Inflammation Induced by a High-Fat-Diet by Modulating the Sirt1/Srebp-1/Pparɑ Pathway in Juvenile Black Seabream (
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 57 citations in OpenAlex.
- Betaine in Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanisms of Action and Therapeutic Potential.Antioxidants (Basel, Switzerland) · 2026Review
- Dietary Methionine Affects Lipid Metabolism and Ferroptosis-Related Responses to Modulate Oxidative Stress Induced by High-Lipid-Diet in Golden Pompano (Antioxidants (Basel, Switzerland) · 2026Article
- Natural liquid betaine dietary supplementation improves growth performance, immuno-antioxidant responses, and stress resistance in Nile tilapia subjected to acute ammonia challenge.Scientific reports · 2026Article
- Omega-3 fatty acids improve lipid metabolism by regulating miR-34a.Scientific reports · 2026Article
- Growth, Health and Physiological Responses of Freshwater-Reared Atlantic Salmon (Animals : an open access journal from MDPI · 2026Article
- Betaine alleviates letrozole-induced polycystic ovarian syndrome in rats by regulating oxidative stress and inflammation and restoring the proliferation-apoptosis balance.Journal of ovarian research · 2025Article
- Protective effect of exercise on metabolic dysfunction‑associated fatty liver disease: Potential epigenetic mechanisms (Review).International journal of molecular medicine · 2025Review
- Dietary Glycine and Methyl Donors Remodel Gut Microbiota to Enhance Collagen Synthesis in Sea Cucumber (Biology · 2025Article
- Betaine Dietary Supplementation: Healthy Aspects in Human and Animal Nutrition.Antioxidants (Basel, Switzerland) · 2025Review
- Article
- Impacts of alfalfa nutrient concentrate on pellet physical attributes, growth performance, metabolism and nutritional quality of rainbow trout,Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Article
- Betaine Alleviated the Ammonia-Induced Apoptosis and Inflammation in the Skin of Largemouth Bass Fed With High-Carbohydrate Diet via Inhibiting MAPK/NFκB-Myd88 Pathway.Aquaculture nutrition · 2025Article
- The multi-protective role of dietary betaine in largemouth bass (Frontiers in physiology · 2025Article
- Exercise-mimicking effects of betaine in chronic disease prevention and management.Frontiers in nutrition · 2025Review
- Wet pulverization combined with temperature cycling strategy for extraction ofFood chemistry: X · 2025Article
- Dietary Betaine Improves Immune Function, Antioxidant Status, Immune-Related Signaling Molecules, and Disease Resistance in Fish Species.Aquaculture nutrition · 2025Review
- Gut MicrobeAquaculture nutrition · 2025Article
- Betaine, a Potential Therapeutic Alternative for the Treatment of Depression.Current drug targets · 2025Review
- Comparative Transcriptome Analysis Reveals the Impact of a High-Fat Diet on Hepatic Metabolic Function in Tilapia (Animals : an open access journal from MDPI · 2024Article
- Effects of Berberine on Lipid Metabolism, Antioxidant Status, and Immune Response in Liver of Tilapia (Antioxidants (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study aimed to elucidate the mechanism of dietary betaine, as a lipid-lowering substance, on the regulation of lipid metabolism and inflammation in juvenile black seabream (
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.