ArticleFrontiers in immunology2021
High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity.
Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 22 citations in OpenAlex.
- Analysis of the immunomodulatory effects of Honeysuckle leaf polysaccharides on cherry valley ducks based on transcriptomic techniques.Poultry science · 2026Article
- Glucose metabolic reprogramming as a driver of immunosuppression in the tumour microenvironment.Clinical and translational medicine · 2026Review
- Alterations of circulating innate lymphoid cells in recent-onset type 1 diabetes.Clinical & translational immunology · 2026Article
- Intrinsic STING of CD8 + T cells regulates self-metabolic reprogramming and memory to exert anti-tumor effects.Cell communication and signaling : CCS · 2025Article
- Hexokinase2-engineered T cells display increased anti-tumor function.Frontiers in immunology · 2025Article
- Genetically engineering glycolysis in T cells increases their antitumor function.Journal for immunotherapy of cancer · 2024Article
- Paclitaxel combined with Compound K inducing pyroptosis of non-small cell lung cancer cells by regulating Treg/Th17 balance.Chinese medicine · 2024Article
- Cytotoxic response of tumor-infiltrating lymphocytes of head and neck cancer slice cultures under mitochondrial dysfunction.Frontiers in oncology · 2024Article
- Effects of altered glycolysis levels on CD8Cell death & disease · 2023Review
- Heterozygous OT-I mice reveal that antigen-specific CD8Aging cell · 2023Article
- Bacille Calmette Guerin (BCG) and prevention of types 1 and 2 diabetes: Results of two observational studies.PloS one · 2023Observational
- Review
- Unspecific CTL Killing Is Enhanced by High GlucoseFrontiers in immunology · 2022Article
- Manipulating T-cell metabolism to enhance immunotherapy in solid tumor.Frontiers in immunology · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cytotoxic T lymphocytes (CTLs) are key players to eliminate tumorigenic or pathogen-infected cells using lytic granules (LG) and Fas ligand (FasL) pathways. Depletion of glucose leads to severely impaired cytotoxic function of CTLs. However, the impact of excessive glucose on CTL functions still remains largely unknown. Here we used primary human CD8
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.