Evidence map›Paper›PMID 34248977›Full record

ArticleFrontiers in immunology2021

HVEM Promotes the Osteogenesis of allo-MSCs by Inhibiting the Secretion of IL-17 and IFN-γ in Vγ4T Cells.

Lei He, Jun Xiao, Lei Song, Rui Zhou, Zhigang Rong, Weifeng He, Fei Dai

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. TAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Lei HeDepartment of Orthopaedics, First Affiliated Hospital, Army Medical University, Chongqing, China.
Jun XiaoSpecial Service Recuperation Center of Rocket Army, Guangzhou, China.
Lei SongDepartment of Orthopaedics, First Affiliated Hospital, Army Medical University, Chongqing, China.
Rui ZhouDepartment of Orthopaedics, First Affiliated Hospital, Army Medical University, Chongqing, China.
Zhigang RongDepartment of Orthopaedics, First Affiliated Hospital, Army Medical University, Chongqing, China.
Weifeng HeState Key Laboratory of Trauma, Institute of Burn Research, Southwest Hospital, Army Medical University, Chongqing, China.
Fei DaiDepartment of Orthopaedics, First Affiliated Hospital, Army Medical University, Chongqing, China.
Army Medical University · CNSouthwest Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone defects are a common orthopaedic concern, and an increasing number of tissue-engineered bones (TEBs) are used to repair bone defects. Allogeneic mesenchymal stem cells (allo-MSCs) are used as seed cells in many approaches to develop TEB constructs, but the immune response caused by allogeneic transplantation may lead to transplant failure. V gamma 4 T (Vγ4T) cells play an important role in mediating the immune response in the early stage after transplantation; therefore, we wanted to verify whether suppressing Vγ4T cells by herpesvirus entry mediator (HVEM)/B and T lymphocyte attenuator (BTLA) signalling can promote MSCs osteogenesis in the transplanted area.

Indexed as

OsteogenesisAnimalsCells, CulturedCoculture TechniquesDiagnostic ImagingFemaleFemurInterferon-gammaInterleukin-17MaleMesenchymal Stem CellsMiceMice, Inbred BALB CMice, Inbred C57BLReceptors, ImmunologicReceptors, Tumor Necrosis Factor, Member 14BTLA protein, mouseInterferon-gammaInterleukin-17Receptors, ImmunologicReceptors, Tumor Necrosis Factor, Member 14Tnfrsf14 protein, mouseHVEM-BTLAIL-17immunomodulatoryMScTissue engineered boneVγ4T cells

Identifiers

PMID34248977
PMCPMC8261146
OpenAlexW3175211242

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.