Evidence map›Paper›PMID 34248958›Full record

ArticleFrontiers in immunology2021

Transcriptional Profiling of Monocytes Deficient in Nuclear Orphan Receptors

David E Phelan, Masahiko Shigemura, Sarah Aldhafiri, Catarina Mota, Thomas J Hall, Jacob I Sznajder, Evelyn P Murphy, Daniel Crean, Eoin P Cummins

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

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  12. Identification of Oxidative Stress-Related Biomarkers in Diabetic Kidney Disease.Evidence-based complementary and alternative medicine : eCAM · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

David E PhelanSchool of Medicine, University College Dublin, Dublin, Ireland.
Masahiko ShigemuraDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Sarah AldhafiriConway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Catarina MotaSchool of Medicine, University College Dublin, Dublin, Ireland.
Thomas J HallSchool of Agriculture and Food Science, University College Dublin, Dublin, Ireland.
Jacob I SznajderDivision of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Evelyn P MurphySchool of Medicine, University of Limerick, Limerick, Ireland.
Daniel CreanConway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin, Ireland.
Eoin P CumminsSchool of Medicine, University College Dublin, Dublin, Ireland.
University College Dublin · IENorthwestern University · USUniversity of Limerick · IE

Funding

Role of hypercapnia on the lung airwaysR01HL147070 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SZNAJDER, JACOB I · 2019 to 2022
$1.9M
NHLBI NIH HHS R01 HL147070
6 · The paper itself

Abstract

The nuclear receptor sub-family 4 group A (NR4A) family are early response genes that encode proteins that are activated in several tissues/cells in response to a variety of stressors. The NR4A family comprises

Indexed as

Antigen PresentationCell MovementComputational BiologyDNA-Binding ProteinsGene Expression RegulationGene Knockdown TechniquesHumansLipopolysaccharidesMonocytesNuclear Receptor Subfamily 4, Group A, Member 2Receptors, SteroidReceptors, Thyroid HormoneRNA-SeqSignal TransductionTHP-1 CellsTranscriptomeDNA-Binding ProteinsLipopolysaccharidesNR4A2 protein, humanNR4A3 protein, humanNuclear Receptor Subfamily 4, Group A, Member 2Receptors, SteroidReceptors, Thyroid Hormonecell signallingmonocytesNR4ANR4A2NR4A3nuclear orphan receptornuclear receptortranscriptomics

Identifiers

PMID34248958
PMCPMC8267906
OpenAlexW3175946695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.