Evidence map›Paper›PMID 34248955›Full record

ArticleFrontiers in immunology

Kinetics of Neutrophil Subsets in Acute, Subacute, and Chronic Inflammation.

Suzanne H Bongers, Na Chen, Erinke van Grinsven, Selma van Staveren, Marwan Hassani, Roy Spijkerman, Lilian Hesselink, Adèle T Lo Tam Loi, Corneli van Aalst, Guus P Leijte and 6 more

Abstract readComparative Study
In one paragraph

Article in Frontiers in immunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed.

  1. Trial
  2. Trial
  3. Neutrophil phenotyping reflects injury severity when base excess and lactate remain normal.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  4. Article
  5. Injury to the thorax is a dominant contributor to post-traumatic neutrophil mediated inflammatory response.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2026
    Article
  6. The role of neutrophils in the pathogenesis of abdominal aortic aneurysms.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  7. Article
  8. Immature leukocyte and plasma-induced cell death reveal subclinical immune activation in EGPA patients in remission.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  9. Article
  10. Article
  11. Immature CD10Frontiers in immunology · 2026
    Article
  12. Multi‑omics reveal neutrophil heterogeneity in sepsis (Review).International journal of molecular medicine · 2025
    Review
  13. Article
  14. Exploratory Study of CD10Scandinavian journal of immunology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Limited impact of traumatic brain injury on the post-traumatic inflammatory cellular response.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Suzanne H BongersCenter for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht, Netherlands.
Na ChenCenter for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht, Netherlands.
Erinke van GrinsvenCenter for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht, Netherlands.
Selma van StaverenCenter for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht, Netherlands.
Marwan HassaniCenter for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht, Netherlands.
Roy SpijkermanCenter for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht, Netherlands.
Lilian HesselinkCenter for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht, Netherlands.
Adèle T Lo Tam LoiDepartment of Respiratory Medicine, University Medical Center Utrecht, Utrecht, Netherlands.
Corneli van AalstCenter for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht, Netherlands.
Guus P LeijteDepartment of Intensive Care, Radboud University Medical Center, Nijmegen, Netherlands.
Matthijs KoxDepartment of Intensive Care, Radboud University Medical Center, Nijmegen, Netherlands.
Peter PickkersDepartment of Intensive Care, Radboud University Medical Center, Nijmegen, Netherlands.
Falco HietbrinkCenter for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht, Netherlands.
Luke P H LeenenCenter for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht, Netherlands.
Leo KoendermanCenter for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht, Netherlands.
Nienke VrisekoopCenter for Translational Immunology (CTI), University Medical Center Utrecht, Utrecht, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

At homeostasis the vast majority of neutrophils in the circulation expresses CD16 and CD62L within a narrow expression range, but this quickly changes in disease. Little is known regarding the changes in kinetics of neutrophils phenotypes in inflammatory conditions. During acute inflammation more heterogeneity was found, characterized by an increase in CD16

Indexed as

Acute DiseaseAdultAgedCell MovementCells, CulturedChronic DiseaseCOVID-19EndotoxemiaFemaleHumansInflammationLipopolysaccharidesL-SelectinMaleMiddle AgedNeutrophilsLipopolysaccharidesL-SelectinReceptors, IgGacute inflammationCD16CD62Lchronic inflammationmorphologyneutrophilsneutrophil subsetssubacute inflammation

Identifiers

PMID34248955
PMCPMC8265311

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.