Evidence map›Paper›PMID 34248954›Full record

ReviewFrontiers in immunology2021

Regulation of the Immune System Development by Glucocorticoids and Sex Hormones.

Linda Quatrini, Biancamaria Ricci, Cecilia Ciancaglini, Nicola Tumino, Lorenzo Moretta

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 47 citations in OpenAlex.

  1. [Mechanism of Qingluo Tongbi Formula for regulating immune-bone erosion in rheumatoid arthritis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023
    Trial
  2. The HIV Reservoir and Immune Landscape Across the Life Course of Women: Implications for Cure Strategies.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026
    Review
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  16. Safety and effectiveness of seahorse extract (Journal of advanced veterinary and animal research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Linda QuatriniDepartment of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Biancamaria RicciDepartment of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Cecilia CiancagliniDepartment of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Nicola TuminoDepartment of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Lorenzo MorettaDepartment of Immunology, IRCCS Bambino Gesù Children's Hospital, Rome, Italy.
Bambino Gesù Children's Hospital · ITIstituti di Ricovero e Cura a Carattere Scientifico · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Through the release of hormones, the neuro-endocrine system regulates the immune system function promoting adaptation of the organism to the external environment and to intrinsic physiological changes. Glucocorticoids (GCs) and sex hormones not only regulate immune responses, but also control the hematopoietic stem cell (HSC) differentiation and subsequent maturation of immune cell subsets. During the development of an organism, this regulation has long-term consequences. Indeed, the effects of GC exposure during the perinatal period become evident in the adulthood. Analogously, in the context of HSC transplantation (HSCT), the immune system development starts

Indexed as

AnimalsGlucocorticoidsGonadal Steroid HormonesHumansImmune SystemGlucocorticoidsGonadal Steroid Hormonesglucocorticoidshematopoietic stem and progenitor cellhematopoietic stem cell transplantationimmune system developmentsex hormones

Identifiers

PMID34248954
PMCPMC8260976
OpenAlexW3176700394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.