Evidence map›Paper›PMID 34248952›Full record

ArticleFrontiers in immunology2021

The Prospect of Nanoparticle Systems for Modulating Immune Cell Polarization During Central Nervous System Infection.

Lee E Korshoj, Wen Shi, Bin Duan, Tammy Kielian

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Bacterial meningitis in Africa.Frontiers in neurology · 2023
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lee E KorshojDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States.
Wen ShiMary & Dick Holland Regenerative Medicine Program, Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Bin DuanMary & Dick Holland Regenerative Medicine Program, Division of Cardiology, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, United States.
Tammy KielianDepartment of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States.
University of Nebraska Medical Center · US

Funding

The S. aureus biofilm lifecycleP01AI083211 · NIAID · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2009 to 2023
$32.1M
Immune mechanisms that promote S. aureus persistence during craniotomy-associated biofilm infectionR01NS107369 · NINDS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI KIELIAN, TAMMY L · 2018 to 2022
$2.1M
NIAID NIH HHS P01 AI083211NINDS NIH HHS R01 NS107369
6 · The paper itself

Abstract

The blood-brain barrier (BBB) selectively restricts the entry of molecules from peripheral circulation into the central nervous system (CNS) parenchyma. Despite this protective barrier, bacteria and other pathogens can still invade the CNS, often as a consequence of immune deficiencies or complications following neurosurgical procedures. These infections are difficult to treat since many bacteria, such as

Indexed as

AnimalsBiofilmsBiological TransportBlood-Brain BarrierCentral Nervous SystemCentral Nervous System InfectionsDrug Delivery SystemsHumansImmunity, CellularImmunomodulationNanoparticlesStaphylococcal InfectionsStaphylococcus aureusVirulencebiofilmblood-brain barriercentral nervous systemimmunometabolisminfectionleukocytesmicrogliananoparticles

Identifiers

PMID34248952
PMCPMC8260670
OpenAlexW3175689264

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.