Evidence map›Paper›PMID 34248948›Full record

ArticleFrontiers in immunology2021

Acute Kidney Injury Induced Lupus Exacerbation Through the Enhanced Neutrophil Extracellular Traps (and Apoptosis) in Fcgr2b Deficient Lupus Mice With Renal Ischemia Reperfusion Injury.

Wilasinee Saisorn, Supichcha Saithong, Pornpimol Phuengmaung, Kanyarat Udompornpitak, Thansita Bhunyakarnjanarat, Peerapat Visitchanakun, Awirut Chareonsappakit, Prapaporn Pisitkun, Direkrit Chiewchengchol, Asada Leelahavanichkul

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Neutrophils and NETs in kidney disease.Nature reviews. Nephrology · 2025
    Review
  10. Article
  11. Review
  12. Review
  13. The Coexistence ofInternational journal of molecular sciences · 2024
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Wilasinee SaisornMedical Microbiology, Interdisciplinary and International Program, Graduate School, Chulalongkorn University, Bangkok, Thailand.
Supichcha SaithongTranslational Research in Inflammation and Immunology Research Unit (TRIRU), Department of Microbiology, Chulalongkorn University, Bangkok, Thailand.
Pornpimol PhuengmaungDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Kanyarat UdompornpitakTranslational Research in Inflammation and Immunology Research Unit (TRIRU), Department of Microbiology, Chulalongkorn University, Bangkok, Thailand.
Thansita BhunyakarnjanaratTranslational Research in Inflammation and Immunology Research Unit (TRIRU), Department of Microbiology, Chulalongkorn University, Bangkok, Thailand.
Peerapat VisitchanakunTranslational Research in Inflammation and Immunology Research Unit (TRIRU), Department of Microbiology, Chulalongkorn University, Bangkok, Thailand.
Awirut ChareonsappakitTranslational Research in Inflammation and Immunology Research Unit (TRIRU), Department of Microbiology, Chulalongkorn University, Bangkok, Thailand.
Prapaporn PisitkunDivision of Allergy, Immunology, and Rheumatology, Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Direkrit ChiewchengcholDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Asada LeelahavanichkulDepartment of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chulalongkorn University · THRamathibodi Hospital · TH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal ischemia is the most common cause of acute kidney injury (AKI) that might be exacerbate lupus activity through neutrophil extracellular traps (NETs) and apoptosis. Here, the renal ischemia reperfusion injury (I/R) was performed in Fc gamma receptor 2b deficient (Fcgr2b-/-) lupus mice and the

Indexed as

ApoptosisAcute Kidney InjuryAnimalsDisease Models, AnimalDisease ProgressionExtracellular TrapsFemaleKidneyLupus NephritisMiceMice, Inbred C57BLMice, KnockoutNeutrophilsPhosphodiesterase 4 InhibitorsProtein Kinase InhibitorsReceptors, IgGFcgr2b protein, mousePhosphodiesterase 4 InhibitorsProtein Kinase InhibitorsReceptors, IgGSyk KinaseSyk protein, mouseacute kidney injuryFcgr2b deficient miceneutrophil extracellular trapsrenal ischemia reperfusion injurysystemic lupus erythematosus

Identifiers

PMID34248948
PMCPMC8269073
OpenAlexW3173475396

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.