ArticleFrontiers in immunology
EASIX for Prediction of Outcome in Hospitalized SARS-CoV-2 Infected Patients.
Article in Frontiers in immunology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05502887 (The Endothelial Cell Dysfunction and Outcome Project for Hematological Neoplasms), which is not on this map. Cited by 46 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Endothelial Cell Dysfunction and Outcome Project for Hematological Neoplasms (EndoCDO-H). A Prospective Registry Study on Endothelial Functional Profile, Intervention Type and Clinical Outcome in Patients With Hematological Neoplasms
Who cites it
46 citing papers in PubMed.
- sST2 is a key outcome biomarker in COVID-19: insights from discovery randomized trial.Scientific reports · 2025Trial
- Endothelial activation and stress index is independently associated with arteriogenic erectile dysfunction: a cross-sectional study.Sexual medicine · 2026Article
- Independent and Incremental Prognostic Value of the Endothelial Activation and Stress Index Beyond the GRACE Score for Predicting 1-Year Mortality in Patients with Non-ST-Segment Elevation Myocardial Infarction.Medicina (Kaunas, Lithuania) · 2026Article
- Endothelial Activation and Stress Index in Different Types of Hypertensive Pregnancy Disorders.Journal of the American Heart Association · 2026Article
- The endothelial activation and stress index (EASIX) predicts hazards of short- and long-term mortality in acute ischemic stroke: a retrospective cohort study.Journal of neurology · 2026Article
- Endothelial stress as reflected by EASIX predicts cardiovascular morbidity and mortality: Insights from a nationally representative cohort.American heart journal plus : cardiology research and practice · 2026Article
- Endothelial Activation and Stress Index as an Indicator of Early Hemodynamic Instability in Critically Ill Patients: A Single-Centre Observational Study.Diagnostics (Basel, Switzerland) · 2026Article
- Dynamic Assessment of Modified EASIX (m-EASIX) at 48 Hours Predicts Adverse Outcomes in Acute Pancreatitis: A Propensity Score-Matched Study.Medicina (Kaunas, Lithuania) · 2026Article
- Regulating effect of genistein on the association of endothelial activation and stress index with atherosclerotic cardiovascular disease risk: a cross-sectional study of the NHANES database.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Predictive value of endothelial activation and stress index for acute kidney injury in hospitalized patients with multiple myeloma.American journal of translational research · 2026Article
- Association between the Endothelial Activation and Stress Index and all-cause mortality in patients with chronic obstructive pulmonary disease.Frontiers in medicine · 2026Article
- EASIX as a moderately effective prognostic marker for mortality in severe acute pancreatitis: a retrospective study.Frontiers in medicine · 2026Article
- Article
- Correlation between EASIX and short- and long-term prognosis of patients with ischemic stroke.BMC neurology · 2025Article
- Endothelial activation and stress index predicts 28-day mortality in patients undergoing CRRT.Biomolecules & biomedicine · 2025Article
- Comprehensive assessment of endothelial dysfunction before cellular therapy: EASIX, local imaging, and systemic biomarkers.Blood vessels, thrombosis & hemostasis · 2025Article
- EASIX as a predictor of 3-year mortality in aortic stenosis patients undergoing TAVR.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
- Endothelial activation and stress index and cardiovascular disease among American population-findings from NHANES 1999-2018.BMC cardiovascular disorders · 2025Article
- Endothelial Activation and Stress Index Is Associated With Adverse Maternal and Perinatal Outcomes in Preeclampsia.Journal of the American Heart Association · 2025Article
- EASIX (endothelial activation and stress index) predicts mortality in patients with coronary artery disease.Clinical research in cardiology : official journal of the German Cardiac Society · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) and has evoked a pandemic that challenges public health-care systems worldwide. Endothelial cell dysfunction plays a key role in pathophysiology, and simple prognosticators may help to optimize allocation of limited resources. Endothelial activation and stress index (EASIX) is a validated predictor of endothelial complications and outcome after allogeneic stem cell transplantation. Aim of this study was to test if EASIX could predict life-threatening complications in patients with COVID-19.
methodsSARS-CoV-2-positive, hospitalized patients were enrolled onto a prospective non-interventional register study (n=100). Biomarkers were assessed at hospital admission. Primary endpoint was severe course of disease (mechanical ventilation and/or death, V/D). Results were validated in 126 patients treated in two independent institutions.
resultsEASIX at admission was a strong predictor of severe course of the disease (odds ratio for a two-fold change 3.4, 95%CI 1.8-6.3, p<0.001), time to V/D (hazard ratio (HR) for a two-fold change 2.0, 95%CI 1.5-2.6, p<0.001) as well as survival (HR for a two-fold change 1.7, 95%CI 1.2-2.5, p=0.006). The effect was retained in multivariable analysis adjusting for age, gender, and comorbidities and could be validated in the independent cohort. At hospital admission EASIX correlated with increased suppressor of tumorigenicity-2, soluble thrombomodulin, angiopoietin-2, CXCL8, CXCL9 and interleukin-18, but not interferon-alpha.
conclusionEASIX is a validated predictor of COVID19 outcome and an easy-to-access tool to segregate patients in need for intensive surveillance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.