ReviewFrontiers in endocrinology2021
Update of Radiofrequency Ablation for Treating Benign and Malignant Thyroid Nodules. The Future Is Now.
Review in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 93 citations in OpenAlex.
- 2025 American Thyroid Association Management Guidelines for Adult Patients with Differentiated Thyroid Cancer.Thyroid : official journal of the American Thyroid Association · 2025Guideline
- Comparison of radiofrequency ablation and surgery for thyroid papillary microcarcinoma: efficacy, safety and life quality.Frontiers in endocrinology · 2024Pooled it
- Ultrasound-guided intermediate cervical plexus block versus local infiltration anesthesia for thermal ablation of benign thyroid nodules: a non-inferior, double-blinded, randomized controlled trial.BMC anesthesiology · 2025Trial
- Radiofrequency versus microwave ablation for non-functioning benign thyroid nodules: a single-institution comparative cohort study.Endocrine · 2026Article
- Development of a prognostic model for thyroid cancer based on mitochondrial metabolism-related genes and immune profiling.World journal of surgical oncology · 2026Article
- The Efficacy of Radiofrequency Ablation in Treating Nonmetastatic Medullary Thyroid Carcinoma: A Case Study.Cancer reports (Hoboken, N.J.) · 2025Article
- Review
- Consensus Thyroid Nodule Radiofrequency Ablation Reporting Guidelines Established Using a Delphi Approach.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 2025Article
- New experimental therapies for glioblastoma: a review of preclinical research.Acta neuropathologica communications · 2025Review
- Radiofrequency ablation for symptomatic, non-functioning thyroid nodules: a single-center retrospective observational study.Annals of surgical treatment and research · 2025Article
- Ankylosing spondylitis management: a narrative review of radiofrequency ablation and naproxen.Pain management · 2025Review
- Landmark Studies in Differentiated Thyroid Cancer.Annals of surgical oncology · 2025Review
- Changes in thyroid surgery over last 25 years.Scientific reports · 2025Article
- Assessment of thermal ablation for treating Bethesda IV thyroid nodules: a systematic review and meta-analysis.Thyroid research · 2025Review
- Case Report: Ultrasound-guided fine-needle aspiration for parathyroid cyst.Frontiers in radiology · 2025Article
- Thermal ablation for ata intermediate-risk papillary thyroid carcinoma: efficacy and safety outcomes in a retrospective cohort.Frontiers in endocrinology · 2025Article
- Treatment outcomes in patients with papillary thyroid cancer undergoing radiofrequency ablation of metastatic lymph nodes.Gland surgery · 2024Article
- Adjustable-tip needles versus fixed-tip needles in radiofrequency ablation of symptomatic benign thyroid nodules: a single-center Italian experience.Journal of ultrasound · 2024Observational
- Multidisciplinary Management of Advanced Thyroid Cancer.JCO oncology practice · 2024Article
- Benign Thyroid Nodule Interventions: A Review and Imaging Considerations for the Interventional Radiologist.Seminars in interventional radiology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 12 institutions in 6 countries.
Funding
Abstract
Thermal and chemical ablation are minimally invasive procedures that avoid removal of the thyroid gland and target symptomatic nodules directly. Internationally, Radiofrequency ablation (RFA) is among one of the most widely used thermal ablative techniques, and is gaining traction in North America. Surgery remains the standard of care for most thyroid cancer, and in the right clinical setting, Active Surveillance (AS) can be a reasonable option for low risk disease. Minimally invasive techniques have emerged as an alternative option for patients deemed high risk for surgery, or for those patients who wish to receive a more active treatment approach compared to AS. Herein, we review the literature on the safety and efficacy of RFA for treating benign non-functioning thyroid nodules, autonomously functioning thyroid nodules, primary small low risk thyroid cancer (namely papillary thyroid cancer) as well as recurrent thyroid cancer.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.