Evidence map›Paper›PMID 34248849›Full record

ArticleFrontiers in endocrinology2021

Identification of Novel Environmental Substances Relevant to Pediatric Graves' Disease.

Qin Xia, Jingjing Liu, Xu Xu, Wei Gu, Kefeng Gu, Xiuli Chen, Rongrong Xie, Dandan Zhang, Haiying Wu, Hui Sun and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Qin XiaDepartment of Endocrinology, Genetics and Metabolism, Children's Hospital of Soochow University, Suzhou, China.
Jingjing LiuDepartment of Biochemistry and Molecular Biology, School of Medical and Biological Sciences, Soochow University, Suzhou, China.
Xu XuDepartment of Pediatric Endocrinology, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, Wuxi, China.
Wei GuDepartment of Endocrinology, Children's Hospital Affiliated to Nanjing Medical University, Nanjing, China.
Kefeng GuDepartment of Pediatric Endocrinology, The Affiliated Wuxi Children's Hospital of Nanjing Medical University, Wuxi, China.
Xiuli ChenDepartment of Endocrinology, Genetics and Metabolism, Children's Hospital of Soochow University, Suzhou, China.
Rongrong XieDepartment of Endocrinology, Genetics and Metabolism, Children's Hospital of Soochow University, Suzhou, China.
Dandan ZhangDepartment of Endocrinology, Genetics and Metabolism, Children's Hospital of Soochow University, Suzhou, China.
Haiying WuDepartment of Endocrinology, Genetics and Metabolism, Children's Hospital of Soochow University, Suzhou, China.
Hui SunDepartment of Endocrinology, Genetics and Metabolism, Children's Hospital of Soochow University, Suzhou, China.
Fengyun WangDepartment of Endocrinology, Genetics and Metabolism, Children's Hospital of Soochow University, Suzhou, China.
Linqi ChenDepartment of Endocrinology, Genetics and Metabolism, Children's Hospital of Soochow University, Suzhou, China.
Ting ChenDepartment of Endocrinology, Genetics and Metabolism, Children's Hospital of Soochow University, Suzhou, China.
Soochow University · CNNanjing Medical University · CNSecond Affiliated Hospital of Nanjing Medical University · CNWuxi People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Graves' disease (GD) is the most common cause of hyperthyroidism, yet a relatively rare disease in the pediatric population. GD is a complex disorder influenced by both genetic and environmental factors. In this study, we aimed to find new environmental factors influencing the pathogenesis of GD. We investigated serum substances in 30 newly diagnosed GD children and 30 age- and gender-matched healthy controls. We measured total iodine by inductively coupled plasma-mass spectrometry (ICP-MS), analyzed perfluorinated compounds

Indexed as

ChildChild, PreschoolEnvironmental ExposureFemaleGene FrequencyGenetic Predisposition to DiseaseGraves DiseaseHumansMaleMass SpectrometryPolymorphism, Single NucleotideRisk FactorsThyroid Function TestsThyroxineTriiodothyronineThyroxineTriiodothyroninechildrenenvironmental substancesGraves’ diseasemetabolomicssingle-nucleotide polymorphisms

Identifiers

PMID34248849
PMCPMC8261246
OpenAlexW3176037279

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.