Evidence map›Paper›PMID 34248680›Full record

ArticleFrontiers in physiology2021

The SPARC DRC: Building a Resource for the Autonomic Nervous System Community.

Mahyar Osanlouy, Anita Bandrowski, Bernard de Bono, David Brooks, Antonino M Cassarà, Richard Christie, Nazanin Ebrahimi, Tom Gillespie, Jeffrey S Grethe, Leonardo A Guercio and 11 more

Abstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed.

  1. Review
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  7. Building and Sustaining Open-Source Medical Device Projects.IEEE transactions on bio-medical engineering · 2025
    Review
  8. Article
  9. Review
  10. Precision non-invasive brain stimulation: anJournal of neural engineering · 2025
    Article
  11. Article
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Mahyar OsanlouyAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Anita BandrowskiDepartment of Neuroscience, University of California, San Diego, San Diego, CA, United States.
Bernard de BonoAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
David BrooksAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Antonino M CassaràIT'IS Foundation, Zurich, Switzerland.
Richard ChristieAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Nazanin EbrahimiAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Tom GillespieDepartment of Neuroscience, University of California, San Diego, San Diego, CA, United States.
Jeffrey S GretheDepartment of Neuroscience, University of California, San Diego, San Diego, CA, United States.
Leonardo A GuercioBlackfynn, Inc., Philadelphia, PA, United States.
Maci HealMBF Bioscience, Williston, VT, United States.
Mabelle LinAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Niels KusterIT'IS Foundation, Zurich, Switzerland.
Maryann E MartoneDepartment of Neuroscience, University of California, San Diego, San Diego, CA, United States.
Esra NeufeldIT'IS Foundation, Zurich, Switzerland.
David P NickersonAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Elias G SoltaniAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
Susan TappanMBF Bioscience, Williston, VT, United States.
Joost B WagenaarBlackfynn, Inc., Philadelphia, PA, United States.
Katie ZhuangIT'IS Foundation, Zurich, Switzerland.
Peter J HunterAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.

Funding

Open Platform for Online Simulations for Stimulating Peripheral Activity to Relieve Conditions – o2S2PARCOT3OD025348 · OD · IT'IS FOUNDATION · PI KUSTER, NIELS · 2017 to 2024
$18.8M
Multi-scale, multi-organ, multi-species SPARC map managementOT3OD025349 · OD · UNIVERSITY OF AUCKLAND · PI HUNTER, PETER JOHN, NICKERSON, DAVID PHILLIP · 2017 to 2024
$16.3M
Pennsieve: A scalable and sustainable platform for scientific data integration and analysisOT3OD025347 · OD · UNIVERSITY OF PENNSYLVANIA · PI WAGENAAR, JOOST B · 2017 to 2024
$15.4M
K-CORE: Curation and Knowledge Management for SPARCOT2OD030541 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DE BONO, BERNARD, MARTONE, MARYANN E · 2020 to 2024
$10.3M
Neurosciences Graduate Training ProgramT32NS061847 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Brenda L Bloodgood · 2008 to 2026
$7.7M
NIH HHS OT2 OD030541NIH HHS OT3 OD025347NIH HHS OT3 OD025348NIH HHS OT3 OD025349NINDS NIH HHS T32 NS061847
6 · The paper itself

Abstract

The Data and Resource Center (DRC) of the NIH-funded SPARC program is developing databases, connectivity maps, and simulation tools for the mammalian autonomic nervous system. The experimental data and mathematical models supplied to the DRC by the SPARC consortium are curated, annotated and semantically linked via a single knowledgebase. A data portal has been developed that allows discovery of data and models both via semantic search and via an interface that includes Google Map-like 2D flatmaps for displaying connectivity, and 3D anatomical organ scaffolds that provide a common coordinate framework for cross-species comparisons. We discuss examples that illustrate the data pipeline, which includes data upload, curation, segmentation (for image data), registration against the flatmaps and scaffolds, and finally display via the web portal, including the link to freely available online computational facilities that will enable neuromodulation hypotheses to be investigated by the autonomic neuroscience community and device manufacturers.

Indexed as

autonomic nervous systemcomputational life sciencesdata annotationdata curationFAIRknowledge managementneural mappingSPARC

Identifiers

PMID34248680
PMCPMC8265045

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.