Evidence map›Paper›PMID 34248678›Full record

ArticleFrontiers in physiology2021

TRP Channel Agonists Activate Different Afferent Neuromodulatory Mechanisms in Guinea Pig Urinary Bladder.

Stephanie L Daugherty, Jonathan M Beckel, Kyoungeun A Kim, Bruce A Freeman, Jiaxin Liu, Shaoyong Wang, William C de Groat, Xiulin Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Research Progress on TRPA1 in Diseases.The Journal of membrane biology · 2023
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Stephanie L DaughertyDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Jonathan M BeckelDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Kyoungeun A KimDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Bruce A FreemanDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Jiaxin LiuDepartment of Urology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
Shaoyong WangDepartment of Urology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
William C de GroatDepartment of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.
Xiulin ZhangDepartment of Urology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
University of Pittsburgh · USSecond Hospital of Shandong University · CN

Funding

Underlying mechanisms controlling urothelial ATP release and their contributions to urinary bladder physiology and pathophysiologyR01DK117884 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKEL, JONATHAN M · 2018 to 2022
$1.8M
Parasympathetic and sympathetic mechanisms underlying bladder nociceptionR01DK111382 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKEL, JONATHAN M · 2017 to 2020
$1.4M
Role of Pannexins in Urinary Bladder PathologyK01DK106115 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKEL, JONATHAN M · 2015 to 2017
$362k
The Lysosome as an ATP Source in the Urothelium and its Role in PathologyR03DK114492 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BECKEL, JONATHAN M · 2017 to 2018
$156k
NIDDK NIH HHS K01 DK106115NIDDK NIH HHS R01 DK111382NIDDK NIH HHS R01 DK117884NIDDK NIH HHS R03 DK114492
6 · The paper itself

Abstract

Activation of TRP channels expressed in urinary bladder afferent nerves and urothelium releases neurotransmitters that influence bladder function. Experiments were undertaken to examine the mechanisms underlying effects of TRPA1 (allyl isothiocyanate, AITC), TRPV1 (capsaicin, CAPS), and TRPC (oleoyl-2-acetyl-sn-glycerol, OAG) agonists on guinea pig bladder activity. Effects of these agonists were compared with effects of nitro-oleic acid (OA-NO

Indexed as

afferent nervesguinea pignitro-oleic acidTRP channelsurinary bladder

Identifiers

PMID34248678
PMCPMC8264756
OpenAlexW3176587928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.