Evidence map›Paper›PMID 34248669›Full record

ArticleFrontiers in physiology2021

Cardiomyocyte Deletion of

Elizabeth A Schroder, Jennifer L Wayland, Kaitlyn M Samuels, Syed F Shah, Don E Burgess, Tanya Seward, Claude S Elayi, Karyn A Esser, Brian P Delisle

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Circadian influences on sudden cardiac death and cardiac electrophysiology.Journal of molecular and cellular cardiology · 2025
    Review
  4. Article
  5. Review
  6. Feeding behavior modifies the circadian variation in RR and QT intervals by distinct mechanisms in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2024
    Article
  7. Review
  8. Review
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Elizabeth A SchroderDepartment of Physiology, University of Kentucky, Lexington, KY, United States.
Jennifer L WaylandDepartment of Physiology, University of Kentucky, Lexington, KY, United States.
Kaitlyn M SamuelsDepartment of Physiology, University of Kentucky, Lexington, KY, United States.
Syed F ShahDepartment of Physiology, University of Kentucky, Lexington, KY, United States.
Don E BurgessDepartment of Physiology, University of Kentucky, Lexington, KY, United States.
Tanya SewardDepartment of Physiology, University of Kentucky, Lexington, KY, United States.
Claude S ElayiCHI Saint Joseph Hospital, Lexington, KY, United States.
Karyn A EsserDepartment of Physiology and Functional Genomics, University of Florida, Gainesville, FL, United States.
Brian P DelisleDepartment of Physiology, University of Kentucky, Lexington, KY, United States.
University of Kentucky · USSaint Joseph Hospital East · USUniversity of Florida · US

Funding

Circadian clock regulation of myocardial ion channel expression and functionR01HL153042 · NHLBI · UNIVERSITY OF FLORIDA · PI DELISLE, BRIAN P, ESSER, KARYN A · 2020 to 2023
$2.6M
Transcriptional Regulation of KCNH2R01HL141343 · NHLBI · UNIVERSITY OF KENTUCKY · PI DELISLE, BRIAN P · 2019 to 2022
$2.3M
NHLBI NIH HHS R01 HL141343NHLBI NIH HHS R01 HL153042
6 · The paper itself

Abstract

Circadian rhythms are generated by cell autonomous circadian clocks that perform a ubiquitous cellular time-keeping function and cell type-specific functions important for normal physiology. Studies show inducing the deletion of the core circadian clock transcription factor

Indexed as

Bmal1circadianelectrophysiologyheartion channellong QT syndromeSCN5A

Identifiers

PMID34248669
PMCPMC8265216
OpenAlexW3177446507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.