Evidence map›Paper›PMID 34248635›Full record

ArticleFrontiers in pharmacology2021

Loureirin B Exerts its Immunosuppressive Effects by Inhibiting STIM1/Orai1 and K

Shujuan Shi, Qianru Zhao, Caihua Ke, Siru Long, Feng Zhang, Xu Zhang, Yi Li, Xinqiao Liu, Hongzhen Hu, Shijin Yin

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Article
  5. Anti-Inflammatory Effects of Alphitolic Acid Isolated fromInternational journal of molecular sciences · 2023
    Article
  6. Function of GSK‑3 signaling in spinal cord injury (Review).Experimental and therapeutic medicine · 2023
    Review
  7. Endosome Traffic Modulates Pro-Inflammatory Signal Transduction in CD4International journal of molecular sciences · 2023
    Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Shujuan ShiDepartment of Chemical Biology, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
Qianru ZhaoDepartment of Chemical Biology, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
Caihua KeDepartment of Chemical Biology, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
Siru LongDepartment of Chemical Biology, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
Feng ZhangDepartment of Chemical Biology, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
Xu ZhangDepartment of Chemical Biology, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
Yi LiDepartment of Chemical Biology, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
Xinqiao LiuDepartment of Chemical Biology, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
Hongzhen HuDepartment of Anesthesiology, the Center for the Study of Itch & Sensory Disorders, Washington University School of Medicine, St. Louis, MO, United States.
Shijin YinDepartment of Chemical Biology, School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan, China.
South Central University for Nationalities · CNWashington University in St. Louis · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Loureirin B (LrB) is a constituent extracted from traditional Chinese medicine Resina Draconis. It has broad biological functions and an impressive immunosuppressive effect that has been supported by numerous studies. However, the molecular mechanisms underlying Loureirin B-induced immune suppression are not fully understood. We previously reported that Loureirin B inhibited K

Indexed as

Ca2+ influxCRISPR/ Cas9IL-2Jurkat T cellKv1.3LrBSTIM1/Orai1

Identifiers

PMID34248635
PMCPMC8268022
OpenAlexW3175868256

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.