Evidence map›Paper›PMID 34248633›Full record

ArticleFrontiers in pharmacology2021

The Effect of a Novel Serine Protease Inhibitor on Inflammation and Intestinal Permeability in a Murine Colitis Transfer Model.

Hanne Van Spaendonk, Hannah Ceuleers, Annemieke Smet, Maya Berg, Jurgen Joossens, Pieter Van der Veken, Sven M Francque, Anne-Marie Lambeir, Joris G De Man, Ingrid De Meester and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Electrophysiological and Proteomic Evidence of Protease-Mediated Pro-nociceptive Signaling in Inflammatory Bowel Disease Patients.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Hanne Van SpaendonkLaboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.
Hannah CeuleersLaboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.
Annemieke SmetLaboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.
Maya BergInfla-Med, Centre of Excellence, University of Antwerp, Antwerp, Belgium.
Jurgen JoossensLaboratory of Medicinal Chemistry, University of Antwerp, Antwerp, Belgium.
Pieter Van der VekenInfla-Med, Centre of Excellence, University of Antwerp, Antwerp, Belgium.
Sven M FrancqueLaboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.
Anne-Marie LambeirInfla-Med, Centre of Excellence, University of Antwerp, Antwerp, Belgium.
Joris G De ManLaboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.
Ingrid De MeesterInfla-Med, Centre of Excellence, University of Antwerp, Antwerp, Belgium.
Koen AugustynsInfla-Med, Centre of Excellence, University of Antwerp, Antwerp, Belgium.
Benedicte Y De WinterLaboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium.
University of Antwerp · BEAntwerp University Hospital · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

intestinal barrierprotease-activated receptorsserine protease inhibitorT cellsT cell transfer colitis mouse model

Identifiers

PMID34248633
PMCPMC8264366
OpenAlexW3177383570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.