Evidence map›Paper›PMID 34248608›Full record

ArticleFrontiers in aging neuroscience2021

Resting-State Functional Connectivity Signatures of Apathy in Community-Living Older Adults.

Jung Yun Jang, S Duke Han, Belinda Yew, Anna E Blanken, Shubir Dutt, Yanrong Li, Jean K Ho, Aimée Gaubert, Daniel A Nation

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Jung Yun JangInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, United States.
S Duke HanDepartment of Family Medicine, University of Southern California, Los Angeles, CA, United States.
Belinda YewDepartment of Psychology, University of Southern California, Los Angeles, CA, United States.
Anna E BlankenDepartment of Psychology, University of Southern California, Los Angeles, CA, United States.
Shubir DuttDepartment of Psychology, University of Southern California, Los Angeles, CA, United States.
Yanrong LiInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, United States.
Jean K HoInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, United States.
Aimée GaubertInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, United States.
Daniel A NationInstitute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, United States.
University of California, Irvine · USUniversity of Southern California · US

Funding

UC Irvine Alzheimer's Disease Research Center Induced Pluripotent Stem Cell CoreP50AG016573 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI LAFERLA, FRANK M · 2000 to 2019
$37.0M
Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's DiseaseP01AG052350 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation, ARTHUR W TOGA · 2016 to 2026
$28.4M
Endothelial progenitor cells and neurovascular injury in the aging brainR01AG064228 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Daniel A Nation · 2019 to 2026
$4.5M
Cerebrovascular resistance in cognitive aging and Alzheimer's disease riskR01AG060049 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NATION, DANIEL A · 2020 to 2023
$2.4M
NIA NIH HHS P01 AG052350NIA NIH HHS P50 AG016573NIA NIH HHS R01 AG060049NIA NIH HHS R01 AG064228
6 · The paper itself

Abstract

Apathy predicts poor outcomes in older adults, and its underlying neural mechanism needs further investigation. We examined the association between symptoms of apathy and functional connectivity (FC) in older adults without stroke or dementia. Participants included 48 individuals (mean age = 70.90) living independently in the community, who underwent resting-state fMRI and completed the Apathy Evaluation Scale (AES). Seed-to-voxel analysis (cluster-level p-FDR <0.05, voxel threshold

Indexed as

apathyfunctional connectivityolder adultsresting-state fMRIreward processingsalience processing

Identifiers

PMID34248608
PMCPMC8267862
OpenAlexW3176990076

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.