Evidence map›Paper›PMID 34247649›Full record

ArticleJournal of nanobiotechnology2021

Sustained zinc release in cooperation with CaP scaffold promoted bone regeneration via directing stem cell fate and triggering a pro-healing immune stimuli.

Xin Huang, Donghua Huang, Ting Zhu, Xiaohua Yu, Kaicheng Xu, Hengyuan Li, Hao Qu, Zhiyuan Zhou, Kui Cheng, Wenjian Wen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 90 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xin Huang *Department of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88# Jiefang Road, Hangzhou, 310009, China.
Donghua Huang *Department of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88# Jiefang Road, Hangzhou, 310009, China.
Ting Zhu *Department of Thoracic Surgery, Shaoxing People's Hospital, Shaoxing Hospital, Zhejiang University School of Medicine, No. 568 Zhongxing North Road, Yuecheng District, Shaoxing, 312000, China.
Xiaohua YuDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88# Jiefang Road, Hangzhou, 310009, China.
Kaicheng XuDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88# Jiefang Road, Hangzhou, 310009, China.
Hengyuan LiDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88# Jiefang Road, Hangzhou, 310009, China.
Hao QuDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88# Jiefang Road, Hangzhou, 310009, China.
Zhiyuan ZhouSchool of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
Kui ChengSchool of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
Wenjian WenSchool of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, China.
Zhaoming YeDepartment of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, 88# Jiefang Road, Hangzhou, 310009, China. yezhaoming@zju.edu.cn.
Second Affiliated Hospital of Zhejiang University · CNZhejiang University · CNShaoxing People's Hospital · CN

Funding

China Postdoctoral Science Foundation 2019M662077China Postdoctoral Science Foundation 2020TQ0259National Key Research and Development Program of China 2018YFC1105400National Natural Science Foundation of China 81201414National Natural Science Foundation of China 82002333Zhejiang Provincial Natural Science Foundation of China LQ21H060004Zhejiang Provincial Natural Science Foundation of China LY19H060007
6 · The paper itself

Abstract

Metal ions have been identified as important bone metabolism regulators and widely used in the field of bone tissue engineering, however their exact role during bone regeneration remains unclear. Herein, the aim of study was to comprehensively explore the interactions between osteoinductive and osteo-immunomodulatory properties of these metal ions. In particular, the osteoinductive role of zinc ions (Zn

Indexed as

AnimalsBone and BonesBone RegenerationCalcium PhosphatesCell DifferentiationCell ProliferationCeramicsDrug LiberationFemaleImmunomodulationMaleMiceOsteogenesisPhosphatidylinositol 3-KinasesPolyestersRatsbeta-tricalcium phosphateCalcium PhosphatesPhosphatidylinositol 3-KinasesPolyesterspoly(lactide)ZincBone regenerationOsteoimmunomodulationOsteoinductionSynergistic osteogenic effectsZinc-loaded CaP bioactive ceramics

Identifiers

PMID34247649
PMCPMC8274038
OpenAlexW3181506783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.