ArticleBMC pulmonary medicine2021
Contrast-enhanced ultrasound guided pleural biopsy improves diagnostic confidence for pleural based lesions: a 3-year prospective study.
Article in BMC pulmonary medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Diagnostic performance and safety of image-guided pleural biopsy and medical thoracoscopy for undiagnosed exudative pleural effusion: a systematic review and network meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2026Pooled it
- Ultrasound-Guided Pleural Needle Biopsy Which Needle for Which Patient: A Prospective Randomized Study.Balkan medical journal · 2025Trial
- Ultrasound-guided biopsy for thoracic lesions: diagnostic performance, safety, and potential role of contrast-enhanced ultrasound.Journal of medical ultrasonics (2001) · 2026Article
- Diagnostic yield and safety of needle-based COnfocaL LAser endomicroscopy and ultrasound-guided pleural BiOpsy in diagnosing patients with unknown pleuRAl effusion: a protocol for a mulTIcenter, randomized cONtrolled trial (COLLABORATION-II).Respiratory research · 2026Article
- The Role of CEUS in the Diagnosis and Follow-Up of Pleuropulmonary Diseases and Interventional Procedures.Journal of clinical medicine · 2026Review
- Advances in thoracic ultrasound.The European respiratory journal · 2026Article
- Advances in the application of different imaging techniques in percutaneous lung biopsy.Frontiers in medicine · 2026Review
- Lung Ultrasound for Pleural Effusion in Cancer Patients: Advanced Ultrasound for Pleural Lesions-A Narrative Review.Cancers · 2025Review
- Article
- Comparison of the application value of contrast-enhanced ultrasound and contrast-enhanced CT in puncture biopsy of peripheral pulmonary lesions.Frontiers in oncology · 2025Article
- Fluoroscopy-Guided Percutaneous Transthoracic Pleural Forceps Biopsy in Patients With Exudative Pleural Effusion.Korean journal of radiology · 2024Article
- Performance of Intraoperative Contrast-Enhanced Ultrasound (Io-CEUS) in the Diagnosis of Primary Lung Cancer.Diagnostics (Basel, Switzerland) · 2024Article
- Imaging of pleural disease.Breathe (Sheffield, England) · 2024Review
- Application of contrast-enhanced ultrasound in renal space-occupying lesion puncture biopsy.BMC medical imaging · 2023Article
- Needle-based confocal laser endomicroscopy-assisted ultrasound-guided pleural biopsy for diagnosis of pleural effusion (with videos).Endoscopic ultrasoundArticle
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the accuracy and safety of contrast-enhanced ultrasound (CEUS) guided biopsy in the diagnosis of radiologically determined pleural based lesions.
methodA prospective study was conducted on patients with radiologically determined pleural based lesions. Patients who met the inclusion criteria received pleural biopsy guided by CEUS to obtain specimens, followed by histomathological and microbiological examinations. After treatment and follow-up, surgical thoracoscopy was performed on cases with undefinite diagnosis.
resultA total of 460 patients were finally included. CEUS showed internal necrosis in 72.17% cases and obvious peripheral vessels in 55.43% cases, both of which were significantly higher than the conventional ultrasound imaged (p < 0.05). The diagnostic accuracy through CEUS guided biopsy sampling was 98.91% (455/460). The microbiological diagnostic yield achieved 71.88% (225/313) in infectious lesions. In 330 cases combined pleural effusion, CEUS guided biopsy increased the diagnostic yield from 60.30% (199 /330) to 98.36% (325 /330) in all cases (p < 0.05), from 15.56% (14/90) to 94.44% (85/90) in malignant lesions (p < 0.01) and from 77.08% (185/240) to 100% (240/240) in infectious lesions (p < 0.05). No serious adverse events occurred.
conclusionCEUS guided biopsy provides a minimally invasive, effective and safe diagnostic biopsy method for pleural lesions. CLINICAL TRIALS REGISTRATION: Chinese Clinical Trial Registry ChiCTR2000029749 (ChiCTR, www.chictr.org.cn ).
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