ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2021
The replaceable master of sex determination: bottom-up hypothesis revisited.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 31 citations in OpenAlex.
- Sex Determination in Sponges.Molecular reproduction and development · 2026Review
- Sex-specific functional evolution of Dmrt1 in African clawed frogs (Xenopus), and the importance of genetic tipping points in developmental biology.PLoS genetics · 2026Article
- Transposable Element-Mediated Cis-Regulation Drives the Evolution of dmrt1 as a Candidate Master Sex-Determining Gene in Black Carp.Molecular biology and evolution · 2025Article
- Gene Duplication, Translocation, and Molecular Evolution ofBiomolecules · 2025Article
- Multiple Origins of Sex Chromosomes in Nothobranchius Killifishes.Molecular ecology · 2025Article
- Sex Differentiation and Long-Distance Gene Flow in the Elusive Antarctic FishEcology and evolution · 2025Article
- Extreme heterochiasmy and high rates of sex-reversed recombination result in large yet homomorphic sex chromosomes in the Emei moustache toad.Genome research · 2025Article
- The Cause-Effect Model of Master Sex Determination Gene Acquisition and the Evolution of Sex Chromosomes.International journal of molecular sciences · 2025Review
- The master male sex determinant Gdf6Y of the turquoise killifish arose through allelic neofunctionalization.Nature communications · 2025Article
- Rapid Sex Chromosome Turnover in African Clawed Frogs (Xenopus) and the Origins of New Sex Chromosomes.Molecular biology and evolution · 2024Article
- One-factor sex determination evolves without linkage between feminizing and masculinizing mutations.Proceedings. Biological sciences · 2024Article
- It's a trap?! Escape from an ancient, ancestral sex chromosome system and implication of Foxl2 as the putative primary sex-determining gene in a lizard (Anguimorpha; Shinisauridae).Evolution; international journal of organic evolution · 2024Article
- It's a Trap?! Escape from an ancient, ancestral sex chromosome system and implication ofbioRxiv : the preprint server for biology · 2023Article
- Polygenic sex determination in vertebrates - is there any such thing?Trends in genetics : TIG · 2023Review
- XY sex determination in a cnidarian.BMC biology · 2023Article
- How to manage without a Y chromosome.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Madagascar Leaf-Tail Geckos (Cells · 2023Article
- Manipulating Insect Sex Determination Pathways for Genetic Pest Management: Opportunities and Challenges.Frontiers in bioengineering and biotechnology · 2022Review
- Expanding the classical paradigm: what we have learnt from vertebrates about sex chromosome evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
- Evolution of master sex determiners: TGF-β signalling pathways at regulatory crossroads.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Different group of vertebrates and invertebrates demonstrate an amazing diversity of gene regulations not only at the top but also at the bottom of the sex determination genetic network. As early as 1995, based on emerging findings in
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.