Evidence map›Paper›PMID 34247356›Full record

ArticleEnvironmental science and pollution research international2021

Determination of intestinal absorption of the paralytic shellfish toxin GTX-5 using the Caco-2 human cell model.

Elsa T Rodrigues, Susana F Nascimento, Cristiana L Pires, Lia P Godinho, Catarina Churro, Maria João Moreno, Miguel A Pardal

Abstract read
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In one paragraph

Article in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Elsa T RodriguesCentre for Functional Ecology (CFE), Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal. etrodrig@uc.pt.ORCID http://orcid.org/0000-0002-9541-7890
Susana F NascimentoCentre for Functional Ecology (CFE), Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal.
Cristiana L PiresCoimbra Chemistry Center (CQC), Department of Chemistry, University of Coimbra, 3004-535, Coimbra, Portugal.
Lia P GodinhoPhytoplankton Laboratory, Division of Oceanography and Marine Environment, Department of the Sea and Marine Resources, Portuguese Institute for the Sea and Atmosphere (IPMA), Rua Alfredo Magalhães Ramalho, 6, 1449-006, Lisbon, Portugal.
Catarina ChurroPhytoplankton Laboratory, Division of Oceanography and Marine Environment, Department of the Sea and Marine Resources, Portuguese Institute for the Sea and Atmosphere (IPMA), Rua Alfredo Magalhães Ramalho, 6, 1449-006, Lisbon, Portugal.
Maria João MorenoCoimbra Chemistry Center (CQC), Department of Chemistry, University of Coimbra, 3004-535, Coimbra, Portugal.
Miguel A PardalCentre for Functional Ecology (CFE), Department of Life Sciences, University of Coimbra, Calçada Martim de Freitas, 3000-456, Coimbra, Portugal.
University of Coimbra · PTPortuguese Sea and Atmosphere Institute · PTUniversidade do Porto · PT

Funding

Fundação para a Ciência e a Tecnologia CEECIND/03543/2017Fundação para a Ciência e a Tecnologia IPMA-2017-39-BPDFundação para a Ciência e a Tecnologia UIDB/00313/2020Fundação para a Ciência e a Tecnologia UIDB/04004/2020Fundação para a Ciência e a Tecnologia UIDB/04423/2020Fundação para a Ciência e a Tecnologia UIDP/00313/2020Fundação para a Ciência e a Tecnologia UIDP/04423/2020
6 · The paper itself

Abstract

Contributing to the human health risk assessment, the present study aims to evaluate the ability of paralytic shellfish toxins (PSTs) to cross the human intestinal epithelium by using the Caco-2 permeability assay. A crude extract prepared from the PST producer dinoflagellate Gymnodinium catenatum strain, GCAT1_L2_16, and the PST analogue gonyautoxin-5 (GTX-5) prepared from a certified reference material (CRM) were tested. In the conditions of the assay, none of the compounds altered Caco-2 viability, or the integrity of cell monolayers. The GTX-5 apparent permeability coefficients are 0.9×10

Indexed as

DinoflagellidaToxins, BiologicalCaco-2 CellsHumansIntestinal AbsorptionShellfishToxins, BiologicalCaco-2 cellsGonyautoxin-5Gymnodinium catenatumIntestinal absorptionParalytic shellfish toxins

Identifiers

PMID34247356
OpenAlexW3179247816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.