Evidence map›Paper›PMID 34247332›Full record

ReviewClinical reviews in allergy & immunology2022

Perioperative Anaphylaxis: Evaluation and Management.

Deepti Vellaichamy Manian, Gerald W Volcheck

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Clinical reviews in allergy & immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06793163 (Diagnosis and Allergen Identification of Perioperative Anaphylaxis), which is not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06793163 recruitingnot on this mapstarted 2025, after this paper: background citation

Diagnosis and Allergen Identification of Perioperative Anaphylaxis: a Multicenter Prospective Cohort Study

TypeobservationalSponsorPeking University First HospitalRan2025 to 2027Enrolled115ConditionsPerioperative/Postoperative Complications, Anaphylaxis, Tryptase, Allergens
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Tranexamic acid-induced anaphylaxis: a systematic review.European journal of clinical pharmacology · 2025
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Acute cerebral infarction caused by severe anaphylactic shock: A case report.Journal of anesthesia and translational medicine · 2026
    Article
  6. Article
  7. Gloving the Surgeon:Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Sustained intraoperative allergic reaction to chlorhexidine: A case report.The journal of allergy and clinical immunology. Global · 2024
    Article
  13. 2023 Beijing Health Data Science Summit.Health data science · 2024
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Deepti Vellaichamy ManianDivision of Allergic Diseases, Mayo Clinic, Rochester, MN, 55905, USA.
Gerald W VolcheckDivision of Allergic Diseases, Mayo Clinic, Rochester, MN, 55905, USA. Volcheck.gerald@mayo.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perioperative anaphylaxis (PA) is a rare but life-threatening condition that poses diagnostic and management challenges in the operating room. The incidence of severe perioperative reactions is estimated to be approximately 1:7000-10,000. Management involves both immediate stabilization of the patient and identifying the culprit agent. Identification is essential to prevent recurrence of the event in subsequent surgeries and to avoid unnecessary labeling of drug allergy. Identifying all possible exposures including medications, disinfectants, latex, and dyes and choosing the appropriate tests are essential for proper evaluation. To identify the culprit, primary testing modalities include tryptase at the time of the reaction with subsequent levels and skin testing with nonirritating concentrations to the medications and substances utilized during the procedure and those potentially used as alternates. This strategy provides guidance for future surgeries and procedures. Close collaboration between the allergy, anesthesiology, and surgery teams is essential for appropriate management of these patients at the time of the reaction, during the post event evaluation and in preparation for subsequent surgeries.

Indexed as

AnaphylaxisDrug HypersensitivityHumansSkin TestsTryptasesTryptasesAnaphylaxisAnesthesiaDrug allergyIntraoperativePerioperative hypersensitivity

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.