Observational studyArchives of gynecology and obstetrics2021
Osteoporotic fractures and subsequent fractures: imminent fracture risk from an analysis of German real-world claims data.
Observational study in Archives of gynecology and obstetrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- The imminent risk of a fracture-existing worldwide data: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022Pooled it
- The association between heart failure and risk of fractures: Pool analysis comprising 260,410 participants.Frontiers in cardiovascular medicine · 2022Pooled it
- Treatment gaps in osteoporosis care following recurrent fractures: a nationwide cohort study.Journal of comparative effectiveness research · 2026Article
- The development and validation of a prediction model for imminent vertebral osteoporotic fracture in postmenopausal women.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Vertebral Fracture as a Predictor of Subsequent Extremity Fractures: A Systematic Review.Journal of clinical medicine · 2026Review
- Medical treatment of osteoporosis in osteoporotic vertebral fractures - Results from the prospective EOFTT multicenter study.Brain & spine · 2026Article
- Article
- [Diagnostics and treatment of osteoporosis in 2025 : An update on current guidelines].Innere Medizin (Heidelberg, Germany) · 2025Review
- Osteoporotic vertebral fractures and subsequent fractures: risk factors from a retrospective observational study of patients with osteoporosis.Frontiers in molecular biosciences · 2025Article
- Following hip fracture, hospital organizational factors associated with prescription of anti-osteoporosis medication on discharge, to address imminent refracture risk: a record-linkage study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2024Article
- Long-term and sequential treatment for osteoporosis.Nature reviews. Endocrinology · 2023Review
- Osteoporosis treatment gap in patients at risk of fracture in Egypt: a multi-center, cross-sectional observational study.Archives of osteoporosis · 2023Observational
- Risk factors of primary and recurrent fractures in postmenopausal osteoporotic Chinese patients: A retrospective analysis study.BMC women's health · 2022Article
- Muscle Strength and Physical Performance Are Associated With Risk of Postfracture Mortality But Not Subsequent Fracture in Men.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2022Article
- Management of patients at very high risk of osteoporotic fractures through sequential treatments.Aging clinical and experimental research · 2022Review
- Potential of Health Insurance Claims Data to Predict Fractures in Older Adults: A Prospective Cohort Study.Clinical epidemiology · 2022Article
- ANTIEPILEPTIC DRUGS AND BONE HEALTH: A COMPREHENSIVE REVIEW AND META-ANALYSIS.Acta endocrinologica (Bucharest, Romania : 2005)Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIn osteoporosis, prior fracture is a strong predictor of subsequent fracture. This study aimed to assess the imminent risk of subsequent fracture following an initial fracture in osteoporosis patients in Germany, and to identify clinical and demographic characteristics that are independently associated with subsequent fracture risk.
methodsIn this retrospective, observational cohort study using German real-world claims data, male and female patients aged ≥ 50 years with osteoporosis who experienced an initial ("index") hip/femur, vertebral, forearm/wrist/hand or shoulder/upper arm fracture between 2010 and 2014 were included. The incidence and timing of subsequent fractures during a 1-year follow-up period were analyzed. Independent risk factors for subsequent fracture were identified by multivariate regression analysis.
resultsA total of 18,354 patients (mean age: 77 years; standard deviation: 9.8) were included. Of these, 2918 (15.9%) suffered a subsequent fracture during the 1-year follow-up period. The incidence of subsequent fracture was higher following an index vertebral fracture (18.0%) than after an index forearm/wrist/hand fracture (14.1%) or index hip/femur fracture (12.1%). Subsequent 1-year fracture incidence was generally higher in older patients. Index fracture type, age, epilepsy/use of antiepileptics, and heart failure were all independently associated with subsequent fracture risk.
conclusionOsteoporosis patients in Germany are at imminent risk of subsequent fracture during the first year following an initial fracture. They should be targeted for immediate post-fracture treatment to reduce the risk of further fractures, especially in the presence of specific risk factors such as old age or index vertebral fracture.
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