ArticleRheumatology (Oxford, England)2022
Long-term weight changes and risk of rheumatoid arthritis among women in a prospective cohort: a marginal structural model approach.
Article in Rheumatology (Oxford, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 17 citations in OpenAlex.
- The association between bariatric surgery and incident rheumatoid arthritis.Rheumatology advances in practice · 2026Article
- A Lymphatic Perspective on Obesity and Inflammatory Arthritis: New Disease-Modifying Potential in Rheumatology.Journal of clinical medicine · 2025Article
- Longitudinal patterns of obesity index changes and risk of incident rheumatoid arthritis: evidence from a population-based cohort.Arthritis research & therapy · 2025Article
- Association between body roundness index and osteoarthritis/rheumatoid arthritis: a cross-sectional study.Scientific reports · 2025Article
- Bone Health in Patients with Rheumatoid Arthritis in Bahrain.Medicina (Kaunas, Lithuania) · 2024Article
- The association of obesity and the risk of rheumatoid arthritis according to abdominal obesity status: a nationwide population-based study in Korea.Rheumatology international · 2024Article
- [Procedures of complementary medicine in rheumatology].Zeitschrift fur Rheumatologie · 2024Review
- Article
- Association between weight-adjusted-waist index and the prevalence of rheumatoid arthritis and osteoarthritis: a population-based study.BMC musculoskeletal disorders · 2023Article
- Lifestyle Factors and Their Influence on Rheumatoid Arthritis: A Narrative Review.Journal of clinical medicine · 2022Review
- Challenges and Opportunities of Targeted Behavioral Interventions for Groups at Risk for Developing Rheumatoid Arthritis.Healthcare (Basel, Switzerland) · 2021Review
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo examine the association of long-term weight change with RA risk in a large prospective cohort study.
methodsThe Nurses' Health Study II started in 1989 (baseline); after exclusions, we studied 108 505 women 25-42 years old without RA. Incident RA was reported by participants and confirmed by medical record review. Body weight was reported biennially through 2015. We investigated two time-varying exposures: weight changes from baseline and from age 18; change was divided into five categories. We used a marginal structural model approach to account for time-varying weight change and covariates.
resultsOver 2 583 266 person-years, with a median follow-up time of 25.3 years, 541 women developed RA. Compared with women with stable weight from baseline, weight change was significantly associated with increased RA risk [weight gain 2-<10 kg: RR = 1.98 (95% CI 1.38, 2.85); 10-<20 kg: RR = 3.28 (95% CI 2.20, 4.89); ≥20 kg: RR = 3.81 (95% CI 2.39, 6.07); and weight loss >2 kg: RR = 2.05 (95% CI 1.28, 3.28)]. Weight gain of 10 kg or more from age 18 compared with stable weight was also associated with increased RA risk [10-< 20 kg: RR = 2.12 (95% CI 1.37, 3.27), ≥20 kg: RR = 2.31 (95% CI 1.50, 3.56)]. Consistent findings were observed for seropositive and seronegative RA.
conclusionLong-term weight gain was strongly associated with increased RA risk in women, with weight gain of ≥20 kg associated with more than a three-fold increased RA risk. Maintenance of healthy weight may be a strategy to prevent or delay RA.
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