Observational studyThe American journal of emergency medicine2021
Predictive value of cardiac markers in the prognosis of COVID-19 in children.
Observational study in The American journal of emergency medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Pooled it
- Prognostic value of cardiac biomarkers and Phoenix criteria in pediatric sepsis: a retrospective cohort study.BMC pediatrics · 2025Article
- Cardiac Manifestations and Emerging Biomarkers in Multisystem Inflammatory Syndrome in Children (MIS-C): A Systematic Review and Meta-Analysis.Life (Basel, Switzerland) · 2025Review
- Prognostic Value of Caspase-3 and Cardiac Troponin I in Assessing Cardiovascular Risk in Pediatric COVID-19 and Multisystem Inflammatory Syndrome.Journal of multidisciplinary healthcare · 2025Article
- Clinical Presentation and Outcomes of Myocarditis Among the COVID-19 Pediatric Population: A Review of 100 Cases.Cureus · 2024Article
- A Comparative Analysis of Pediatric Emergency Department Admissions Before and During the COVID-19 Pandemic.Cureus · 2024Article
- Assessing the prognostic utility of clinical and radiomic features for COVID-19 patients admitted to ICU: challenges and lessons learned.Harvard data science review · 2024Article
- Article
- The effect of full blood count and cardiac biomarkers on prognosis in carbon monoxide poisoning in children.Irish journal of medical science · 2023Article
- COVID-19 Biomarkers Comparison: Children, Adults and Elders.Medicina (Kaunas, Lithuania) · 2023Article
- The Evaluation of Troponin I Levels and Myocarditis in Children with COVID-19: A Pediatric Single-Center Experience.Pediatric cardiology · 2023Article
- Platelet role in the prediction of MIS-C severity.Frontiers in pediatrics · 2023Article
- Cardiac Involvement in Children Affected by COVID-19: Clinical Features and Diagnosis.Diagnostics (Basel, Switzerland) · 2022Review
- COVID-19 Inflammatory Markers and Vitamin D Relationship in Pediatric Patients.Life (Basel, Switzerland) · 2022Article
- Article
- Evaluation of Pulmonary Functions After Discharge in Pediatric Patients with COVID-19: A Prospective Study.Sisli Etfal Hastanesi tip bulteni · 2022Article
- Cardiac Biomarkers in COVID-19: A Narrative Review.EJIFCC · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimOccasionally, children with COVID-19 may develop arrhythmia, myocarditis, and cardiogenic shock involving multisystemic inflammatory syndrome in children (MIS-C). This study aimed to identify the laboratory parameters that may predict early cardiovascular involvement in these patients. MATERIALS AND
methodsData of 320 pediatric patients, aged 0-18 years (average age, 10.46 ± 5.77 years; 156 female), with positive COVID-19 reverse transcription-polymerase chain reaction test and with cardiac biomarkers at the time of admission to the pediatric emergency department were retrospectively scanned. The age, sex, COVID-19-associated symptoms, pro-brain natriuretic peptide (proBNP), CK-MB, and troponin I levels of the patients were recorded.
resultsFever was noted in 58.1% of the patients, cough in 29.7%, diarrhea in 7.8%, headache in 14.7%, sore throat in 17.8%, weakness in 17.8%, abdominal pain in 5%, loss of taste in 4.1%, loss of smell in 5.3%, nausea in 3.4%, vomiting in 3.8%, nasal discharge in 4.4%, muscle pain in 5%, and loss of appetite in 3.1%. The proBNP value ≥282 ng/L predicted the development of MIS-C with 100% sensitivity and 93% specificity [AUC: 0.985 (0.959-1), P < 0.001]; CK-MB value ≥2.95 with 80% sensitivity and 77.6% specificity [AUC: 0.792 (0.581-1), P = 0.026]; and troponin I value ≥0.03 with 60% sensitivity and 99.2% specificity [AUC: 0.794 (0.524-1)].
conclusionsCardiac markers (proBNP and troponin I), especially proBNP, could be used to detect early diagnosis of cardiac involvement and/or MIS-C in pediatric patients with COVID-19 and to predict related morbidity and mortality.
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