ArticleNeurobiology of aging2021
Age-related dedifferentiation and hyperdifferentiation of perceptual and mnemonic representations.
Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 43 citations in OpenAlex.
- White-matter connectivity shapes visual and semantic representations in the aging brain.bioRxiv : the preprint server for biology · 2026Article
- Dopaminergic mechanisms supporting hippocampal postencoding dynamics in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- What makes memories vivid?Journal of experimental psychology. General · 2026Article
- Neural correlates and reinstatement of recent and remote memory in children and young adults.eLife · 2025Article
- The cognitive neuroscience of memory representations.Neuroscience and biobehavioral reviews · 2025Review
- Spontaneous fluctuations in global connectivity reflect transitions between states of high and low prediction error.bioRxiv : the preprint server for biology · 2025Article
- Aging and episodic memory specificity: Evidence challenging a domain-general pattern separation decline.PloS one · 2025Article
- Connectivity analyses for task-based fMRI.Physics of life reviews · 2024Review
- Mnemonic But Not Contextual Feedback Signals Defy Dedifferentiation in the Aging Early Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dissociative Effects of Age on Neural Differentiation at the Category and Item Levels.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Effects of Aging on Successful Object Encoding: Enhanced Semantic Representations Compensate for Impaired Visual Representations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Age differences in neural distinctiveness during memory encoding, retrieval, and reinstatement.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Visual attention during seeing for speaking in healthy aging.Psychology and aging · 2023Article
- Autobiographical event memory and aging: older adults get the gist.Trends in cognitive sciences · 2022Review
- Age-related neural dedifferentiation for individual stimuli: an across-participant pattern similarity analysis.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022Article
- Understanding associative false memories in aging using multivariate analyses.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2022Article
- Low-Resolution Neurocognitive Aging and Cognition: An Embodied Perspective.Frontiers in systems neuroscience · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Preliminary evidence indicates that occipito-temporal activation patterns for different visual stimuli are less distinct in older (OAs) than younger (YAs) adults, suggesting a dedifferentiation of visual representations with aging. Yet, it is unclear if this deficit (1) affects only sensory or also categorical aspects of representations during visual perception (perceptual representations), and (2) affects only perceptual or also mnemonic representations. To investigate these issues, we fMRI-scanned YAs and OAs viewing and then remembering visual scenes. First, using representational similarity analyses, we distinguished sensory vs. categorical features of perceptual representations. We found that, compared to YAs, sensory features in early visual cortex were less differentiated in OAs (i.e., age-related dedifferentiation), replicating previous research, whereas categorical features in anterior temporal lobe (ATL) were more differentiated in OAs. This is, to our knowledge, the first report of an age-related hyperdifferentiation. Second, we assessed the quality of mnemonic representations by measuring encoding-retrieval similarity (ERS) in activation patterns. We found that aging impaired mnemonic representations in early visual cortex and hippocampus but enhanced mnemonic representations in ATL. Thus, both perceptual and mnemonic representations in ATL were enhanced by aging. In sum, our findings suggest that aging impairs visual and mnemonic representations in posterior brain regions but enhances them in anterior regions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.