ArticleEnvironmental research2021
Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio.
Article in Environmental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Developmental manganese exposure, but not concurrent lead, alters social processing selectively in male mice.iScience · 2026Article
- Article
- Characterization of extracellular vesicles and miRNA released by cerebral organoids.Current research in toxicology · 2025Article
- Effects of Blood Lead Levels <10 µg/dL in School-Age Children and Adolescents: A Scoping Review.Pediatrics · 2024Article
- Sex-specific associations of a ferroalloy metal mixture with motor function in Italian adolescents.Environmental epidemiology (Philadelphia, Pa.) · 2024Article
- Article
- Comparative susceptibility of children and adults to neurological effects of inhaled manganese: A review of the published literature.Environmental research · 2023Review
- Quantitative fluoride imaging of teeth using CaF emission by laser induced breakdown spectroscopy.Journal of analytical atomic spectrometry · 2023Article
- Animal Models of Childhood Exposure to Lead or Manganese: Evidence for Impaired Attention, Impulse Control, and Affect Regulation and Assessment of Potential Therapies.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Environmental Risk Factors and Cognitive Outcomes in Psychosis: Pre-, Perinatal, and Early Life Adversity.Current topics in behavioral neurosciences · 2023Review
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
Exposure to metal mixtures may lead to health impacts greater than the effects associated with singular exposures. Two common childhood environmental exposures, manganese (Mn) and lead (Pb), are associated with similar adverse neurodevelopmental effects; however, the effects surrounding concurrent exposure to both metals remain unclear. We study the impact of joint exposure to Mn and Pb on cognitive performance in school-aged children participating in the Communities Actively Researching Exposure Study (CARES) based in East Liverpool, Ohio. Blood Pb levels were measured for each child (geometric mean (GM) = 1.13 μg/dL, range 0.30 μg/dL - 6.64 μg/dL). Mn was measured in participant blood, hair, and toenails with GMs of 10.1 μg/L, 360 ng/g, 0.974 μg/g, respectively. Trained team members administered the Wechsler Intelligence Scale for Children-IV (WISC-IV) to assess intelligence quotient (IQ). The WISC-IV provides scores for Full Scale IQ, Perceptual Reasoning, Processing Speed, Working Memory, and Verbal Comprehension. Interactions between blood Pb and all Mn biomarkers were tested in linear models adjusted for child sex, household income, and serum cotinine. Separate regression models were run for each of the Mn biomarkers. The cohort was comprised of 106 children with a mean age of 8.4 years. Interactions between blood Pb and hair Mn were significant (p < 0.05) for four out of the five IQ domains. The effect of blood Pb on IQ was more pronounced at higher levels of hair and toenail Mn. No significant associations were observed when characterizing the main effect of Mn using blood. Uncovering the health impacts associated with exposure mixtures is critical to understanding the impact of real-life conditions. Our findings suggest that joint exposure to Mn and Pb may produce heightened neurocognitive impacts even at blood Pb levels below the CDC reference concentration of 5 μg/dL.
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