ArticlePsychiatry research2021
Predictors of social functioning and quality of life in schizophrenia and autism spectrum disorder.
Article in Psychiatry research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Predictors of Health-Related Quality of Life in Neurodivergent Children: A Systematic Review.Clinical child and family psychology review · 2024Pooled it
- The social cognitive and neural mechanisms that underlie social functioning in individuals with schizophrenia - a review.Translational psychiatry · 2023Pooled it
- Methodological issues in social cognition research in autism spectrum disorder and schizophrenia spectrum disorder: a systematic review.Psychological medicine · 2023Pooled it
- Cerebellar mitochondrial dysfunction coincides with structural and behavioral abnormalities in 3q29Del mice.bioRxiv : the preprint server for biology · 2026Article
- Commentary on Ziermans, Hadjúk, Pinkham et al. "Call to action on social cognition measures in clinical research" and on Happé's commentary to the call to action.Schizophrenia research. Cognition · 2026Article
- Comparative Analysis of Social Cognitive and Neurocognitive Performance Across Autism and Schizophrenia Spectrum Disorders.Schizophrenia bulletin · 2026Article
- Social cognitive deficits and their relationship with clinical symptoms in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2026Article
- Quality-of-life assessment in autistic adults with lower support needs: gaps and emerging challenges.Frontiers in psychiatry · 2026Review
- Autistic traits, psychosis proneness, and empathy in preadolescents: A network analysis.Scientific reports · 2025Article
- Social functioning and frontal alpha asymmetry in schizophrenia.Journal of psychiatric research · 2025Article
- Emotional Contagion and Emotional Mimicry in Individuals with Schizophrenia: A Systematic Review.Journal of clinical medicine · 2024Review
- Disentangling negative and positive symptoms in schizophrenia and autism spectrum disorder.Schizophrenia research · 2024Article
- Empathy deficit in male patients with schizophrenia and its relationships with impulsivity and premeditated violence.Frontiers in psychiatry · 2023Article
- Benefits of Social Contact in Individuals With Psychotic Symptoms: Do Closeness of the Contact and Empathic Skills Make the Difference?Frontiers in psychology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Schizophrenia (SZ) and Autism Spectrum Disorder (ASD) show overlap in social cognitive and functioning impairments. Proposed predictors of social functioning (SF) and quality of life (QL) have been symptom severity, IQ and social cognition. Empathy has rarely been compared between ASD and SZ and its predictive power on functional outcomes is unclear. We investigated general, affective, and cognitive empathy in 46 SZ, 30 ASD and 51 healthy controls (HC) and examined their relationship to SF and QL in addition to IQ and symptoms. SZ and ASD shared deficits in general and cognitive empathy, and personal distress, but only SZ showed deficits in affective empathy. Both groups showed lower performance-based empathy scores and only ASD showed slower responses compared to HC. Negative symptoms predicted QL in both groups, the more negative symptoms the worse QL (ASD t=-3.22; SZ t= -3.43; p<0.01), and only in ASD, IQ predicted QL, the higher the IQ the higher QL (t = 2.1; p<0.05). In ASD only, negative symptoms predicted SF, the greater negative symptoms the worse SF (t=-3.45; p<0.01), and communication deficits predicted SF, the higher deficits, the higher SF (t = 2.9; p<0.01). Negative symptoms but not empathy were the shared predictors of functioning across ASD and SZ.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.