Evidence map›Paper›PMID 34245839›Full record

ReviewBiochimica et biophysica acta. Reviews on cancer2021

Machine Learning in Epigenomics: Insights into Cancer Biology and Medicine.

Emre Arslan, Jonathan Schulz, Kunal Rai

Open access · greenAbstract readReview
In one paragraph

Review in Biochimica et biophysica acta. Reviews on cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

  1. PROTACs in cancer therapy: targeted degradation of GPX4, PARP and epigenetic regulators.Journal of enzyme inhibition and medicinal chemistry · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Emre ArslanDepartment of Genomic Medicine, MD Anderson Cancer Center, Houston, TX 77030, United States of America.
Jonathan SchulzDepartment of Genomic Medicine, MD Anderson Cancer Center, Houston, TX 77030, United States of America.
Kunal RaiDepartment of Genomic Medicine, MD Anderson Cancer Center, Houston, TX 77030, United States of America. Electronic address: krai@mdanderson.org.
The University of Texas MD Anderson Cancer Center · US

Funding

Synthetic Lethal Targeting of CREBBP/EP300 in Head and Neck Squamous Cell CarcinomaR01DE028061 · NIDCR · YALE UNIVERSITY · PI PICKERING, CURTIS, SKINNER, HEATH DEVIN · 2019 to 2023
$2.8M
UCHL5 as a regulator and therapeutic target in metastatic melanomaR01CA245395 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI RAI, KUNAL · 2020 to 2024
$2.0M
Role of UBR7, a novel H2BK120 E3 ubiquitin ligase, in suppression of breast cancerR01CA226269 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI RAI, KUNAL · 2020 to 2024
$1.8M
Role of KMT2D and aberrant enhancers in modulating tumor microenvironment in melanomaR01CA222214 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI RAI, KUNAL · 2018 to 2022
$1.8M
Epigenetics of Melanoma MetastasisR00CA160578 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI RAI, KUNAL · 2015 to 2017
$747k
Co-operative roles for YAP1 and UCHL5 in cancer progression and therapyR21CA231654 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI RAI, KUNAL · 2018 to 2019
$378k
NCI NIH HHS R00 CA160578NCI NIH HHS R01 CA222214NCI NIH HHS R01 CA226269NCI NIH HHS R01 CA245395NCI NIH HHS R21 CA231654NIDCR NIH HHS R01 DE028061
6 · The paper itself

Abstract

The recent deluge of genome-wide technologies for the mapping of the epigenome and resulting data in cancer samples has provided the opportunity for gaining insights into and understanding the roles of epigenetic processes in cancer. However, the complexity, high-dimensionality, sparsity, and noise associated with these data pose challenges for extensive integrative analyses. Machine Learning (ML) algorithms are particularly suited for epigenomic data analyses due to their flexibility and ability to learn underlying hidden structures. We will discuss four overlapping but distinct major categories under ML: dimensionality reduction, unsupervised methods, supervised methods, and deep learning (DL). We review the preferred use cases of these algorithms in analyses of cancer epigenomics data with the hope to provide an overview of how ML approaches can be used to explore fundamental questions on the roles of epigenome in cancer biology and medicine.

Indexed as

BiologyEpigenomicsHumansMachine LearningMedicineCancerChromatinDeep learningEpigenomicsMachine learning

Identifiers

PMID34245839
PMCPMC8595561
OpenAlexW3181440472

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.