Evidence map›Paper›PMID 34245829›Full record

ArticleGenomics2021

The molecular mechanisms of oxygen-sensing in human ductus arteriosus smooth muscle cells: A comprehensive transcriptome profile reveals a central role for mitochondria.

Rachel E T Bentley, Charles C T Hindmarch, Kimberly J Dunham-Snary, Brooke Snetsinger, Jeffrey D Mewburn, Arthur Thébaud, Patricia D A Lima, Bernard Thébaud, Stephen L Archer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Rachel E T BentleyDepartment of Medicine, Queen's University, Kingston, Ontario, Canada.
Charles C T HindmarchDepartment of Medicine, Queen's University, Kingston, Ontario, Canada; QCPU, Queen's Cardiopulmonary Unit, Translational Institute of Medicine (TIME), Department of Medicine, Queen's University, Canada.
Kimberly J Dunham-SnaryDepartment of Medicine, Queen's University, Kingston, Ontario, Canada; Department of Biomedical and Molecular Science, Queen's University, Canada.
Brooke SnetsingerQCPU, Queen's Cardiopulmonary Unit, Translational Institute of Medicine (TIME), Department of Medicine, Queen's University, Canada.
Jeffrey D MewburnDepartment of Biomedical and Molecular Science, Queen's University, Canada.
Arthur ThébaudDepartment of Kinesiology and Health Studies, Queen's University, Canada.
Patricia D A LimaQCPU, Queen's Cardiopulmonary Unit, Translational Institute of Medicine (TIME), Department of Medicine, Queen's University, Canada.
Bernard ThébaudOttawa Hospital Research Institute, Regenerative Medicine Program, Ottawa, Ontario, Canada; Department of Pediatrics, Division of Neonatology, Children's Hospital of Eastern Ontario, Ottawa, Ontario, Canada; Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa, Ontario, Canada; Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada.
Stephen L ArcherDepartment of Medicine, Queen's University, Kingston, Ontario, Canada; QCPU, Queen's Cardiopulmonary Unit, Translational Institute of Medicine (TIME), Department of Medicine, Queen's University, Canada. Electronic address: stephen.archer@queensu.ca.
Queen's University · CAOttawa Hospital · CA

Funding

O2 sensing in the human and rabbit ductus arteriosus.R01HL071115 · NHLBI · UNIVERSITY OF CHICAGO · PI ARCHER, STEPHEN L · 2004 to 2015
$3.1M
The Role of DRP-1 and Mitochondrial Fission in Pulmonary Arterial HypertensionR01HL113003 · NHLBI · QUEEN'S UNIVERSITY AT KINGSTON · PI ARCHER, STEPHEN L · 2013 to 2016
$1.1M
Impaired mitochondrial fusion in pulmonary arterial hypertensionRC1HL099462 · NHLBI · UNIVERSITY OF CHICAGO · PI ARCHER, STEPHEN L · 2009 to 2010
$1.0M
NHLBI NIH HHS R01 HL071115NHLBI NIH HHS R01 HL113003NHLBI NIH HHS RC1 HL099462
6 · The paper itself

Abstract

The ductus arteriosus (DA) connects the fetal pulmonary artery and aorta, diverting placentally oxygenated blood from the developing lungs to the systemic circulation. The DA constricts in response to increases in oxygen (O

Indexed as

Ductus ArteriosusDuctus Arteriosus, PatentPremature BirthEndothelial CellsHumansInfant, NewbornMitochondriaMyocytes, Smooth MuscleOxygenTranscriptomeVasoconstrictionOxygenCREBBP (Crebb binding protein)EP300 (Histone Acetyltransferase P300)NADH-ubiquinone oxidoreductase (NDUF)Nucleoside biosynthesisPatent ductus arteriosusProstaglandin E synthase (PTGES)RNAsequencing

Identifiers

PMID34245829
PMCPMC10659099
OpenAlexW3177674951

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.