Evidence map›Paper›PMID 34245793›Full record

ArticleInternational journal of cardiology2021

Health-related quality of life and incident cardiovascular disease events in community-dwelling older people: A prospective cohort study.

Aung Zaw Zaw Phyo, Joanne Ryan, David A Gonzalez-Chica, Nigel P Stocks, Christopher M Reid, Andrew M Tonkin, Robyn L Woods, Mark R Nelson, Anne M Murray, Danijela Gasevic and 2 more

Open access · greenAbstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

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  15. Impact of economic factors, social health and stressful life events on physical health-related quality of life trajectories in older Australians.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 4 countries.

Aung Zaw Zaw PhyoSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Joanne RyanSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
David A Gonzalez-ChicaDiscipline of General Practice, Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia; Adelaide Rural Clinical School, University of Adelaide, Adelaide, SA 5005, Australia.
Nigel P StocksDiscipline of General Practice, Adelaide Medical School, University of Adelaide, Adelaide, SA 5005, Australia.
Christopher M ReidSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia; School of Public Health, Curtin University, Perth, WA 6102, Australia.
Andrew M TonkinSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Robyn L WoodsSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia.
Mark R NelsonSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia; Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7000, Australia.
Anne M MurrayBerman Center for Outcomes and Clinical Research, Hennepin HealthCare Research Institute, Hennepin HealthCare, Minneapolis, Minnesota, MN 55415, United States; Division of Geriatrics, Department of Medicine, Hennepin HealthCare and University of Minnesota, Minneapolis, Minnesota, MN 55415, United States.
Danijela GasevicSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia; Usher Institute, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, UK.
Rosanne Freak-PoliSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia; Department of Epidemiology, Erasmus Medical Centre, 3015 GD Rotterdam, The Netherlands. Electronic address: Rosanne.Freak-Poli@monash.edu.
ASPREE Investigator Group
Monash University · AUUniversity of Adelaide · AUUniversity of Edinburgh · GBUniversity of Minnesota · US

Funding

ASPirin in Reducing Events in the ElderlyU01AG029824 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MCNEIL, JOHN JAMES, MURRAY, ANNE M · 2009 to 2018
$64.6M
Main Administrative CoreU19AG062682 · NIA · HENNEPIN HEALTHCARE RESEARCH INSTITUTE · PI MURRAY, ANNE M · 2019 to 2023
$42.9M
Research Education CoreP30AG024824 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Neil Alexander · 2004 to 2026
$29.2M
NIA NIH HHS P30 AG024824NIA NIH HHS U01 AG029824NIA NIH HHS U19 AG062682
6 · The paper itself

Abstract

backgroundLower health-related quality of life (HRQoL) has been shown to predict a higher risk of hospital readmission and mortality in patients with cardiovascular disease (CVD). Few studies have explored the associations between HRQoL and incident CVD. We explored the associations between baseline HRQoL and incident and fatal CVD in community-dwelling older people in Australia and the United States.

methodsLongitudinal study using ASPirin in Reducing Events in the Elderly (ASPREE) trial data. This includes 19,106 individuals aged 65-98 years, initially free of CVD, dementia, or disability, and followed between March 2010 and June 2017. The physical (PCS) and mental component scores (MCS) of HRQoL were assessed using the SF-12 questionnaire. Incident major adverse CVD events included fatal CVD (death due to atherothrombotic CVD), hospitalizations for heart failure, myocardial infarction or stroke. Analyses were performed using Cox proportional-hazard regression.

resultsOver a median 4.7 follow-up years, there were 922 incident CVD events, 203 fatal CVD events, 171 hospitalizations for heart failure, 355 fatal or nonfatal myocardial infarction and 403 fatal or nonfatal strokes. After adjustment for sociodemographic, health-related behaviours and clinical measures, a 10-unit higher PCS, but not MCS, was associated with a 14% lower risk of incident CVD, 28% lower risk of hospitalization for heart failure and 15% lower risk of myocardial infarction. Neither PCS nor MCS was associated with fatal CVD events or stroke.

conclusionPhysical HRQoL can be used in combination with clinical data to identify the incident CVD risk among older individuals.

Indexed as

Cardiovascular DiseasesQuality of LifeAgedHealth StatusHeart Disease Risk FactorsHumansIndependent LivingLongitudinal StudiesPerceptionProspective StudiesRisk FactorsUnited StatesAgedCardiovascular diseasesIncidenceQuality of lifeRisk factors

Identifiers

PMID34245793
PMCPMC9993351
OpenAlexW3181295035

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.