ArticleChest2021
IL-33 Depletion in COVID-19 Lungs.
Abstract readLetter
In one paragraph
Article in Chest, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Blocking interleukin 33 reduces joint, systemic, and lung inflammatory responses in the combined collagen-induced arthritis-inhalant endotoxin exposure model.The Journal of pharmacology and experimental therapeutics · 2026Article
- IL-33 is associated with alveolar dysfunction in patients with viral lower respiratory tract disease.Mucosal immunology · 2025Article
- Lung-delivered IL-10 mitigates Lung inflammation induced by repeated endotoxin exposures in male mice.Physiological reports · 2025Article
- SARS-CoV-2 and its ORF3a, E and M viroporins activate inflammasome in human macrophages and induce of IL-1α in pulmonary epithelial and endothelial cells.Cell death discovery · 2024Article
- SARS-CoV-2 Lurking and Lingering in the Depths of Lungs.American journal of respiratory and critical care medicine · 2024Article
- Airway Epithelial-Derived Immune Mediators in COVID-19.Viruses · 2023Review
- The Correlation of Serum Calpain 1 Activity and Concentrations of Interleukin 33 in COVID-19 Acute Respiratory Distress Syndrome.Biomedicines · 2023Article
- Interleukin-22 and interleukin-33 show up-regulated levels in the serum of patients with mild/moderate Coronavirus disease 2019.Beni-Suef University journal of basic and applied sciences · 2023Article
- Interleukin (IL)-33 immunobiology in asthma and airway inflammatory diseases.The Journal of asthma : official journal of the Association for the Care of Asthma · 2022Article
- IL-33 and the Cytokine Storm in COVID-19: From a Potential Immunological Relationship towards Precision Medicine.International journal of molecular sciences · 2022Review
- Post-endotoxin exposure-induced lung inflammation and resolution consequences beneficially impacted by lung-delivered IL-10 therapy.Scientific reports · 2022Article
- The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2022Article
- Increased susceptibility to organic dust exposure-induced inflammatory lung disease with enhanced rheumatoid arthritis-associated autoantigen expression in HLA-DR4 transgenic mice.Respiratory research · 2022Article
- Involvement of Il-33 in the Pathogenesis and Prognosis of Major Respiratory Viral Infections: Future Perspectives for Personalized Therapy.Biomedicines · 2022Review
- The Role of Cytokines and Chemokines in Severe Acute Respiratory Syndrome Coronavirus 2 Infections.Frontiers in immunology · 2022Review
- The impact of airborne endotoxin exposure on rheumatoid arthritis-related joint damage, autoantigen expression, autoimmunity, and lung disease.International immunopharmacology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Rohit GauravDivision of Allergy & Immunology, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE.
Daniel R AndersonDepartment of Cardiovascular Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE.
Stanley J RadioPathology & Microbiology, University of Nebraska Medical Center (UNMC), Omaha, NE.
Kristina L BaileyPulmonary Critical Care & Sleep, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE; VA Nebraska Western Iowa Health Care System, Omaha, NE.
Bryant R EnglandRheumatology & Immunology, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE; VA Nebraska Western Iowa Health Care System, Omaha, NE.
Ted R MikulsRheumatology & Immunology, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE; VA Nebraska Western Iowa Health Care System, Omaha, NE.
Geoffrey M ThieleRheumatology & Immunology, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE.
Heather M StrahPulmonary Critical Care & Sleep, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE.
Debra J RombergerPulmonary Critical Care & Sleep, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE; VA Nebraska Western Iowa Health Care System, Omaha, NE.
Todd A WyattPulmonary Critical Care & Sleep, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE; VA Nebraska Western Iowa Health Care System, Omaha, NE; Environmental, Agricultural & Occupational Health, UNMC, Omaha, NE.
John D DickinsonPulmonary Critical Care & Sleep, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE.
Michael J DuryeeRheumatology & Immunology, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE.
Dawn M KatafiaszPulmonary Critical Care & Sleep, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE.
Amy J NelsonDivision of Allergy & Immunology, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE.
Jill A PooleDivision of Allergy & Immunology, Department of Internal Medicine, University of Nebraska Medical Center (UNMC), Omaha, NE. Electronic address: japoole@unmc.edu.
Funding
UNMC/EPPLEY CANCER CENTER SUPPORT GRANTP30CA036727 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Amy M Overby · 1985 to 2026
$55.0MTracking and Evaluation CoreU54GM115458 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI HOLSTEIN, SARAH A · 2016 to 2025
$42.8MSurveillance of Agricultural Injuries in the Central States RegionsU54OH010162 · OH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI RAUTIAINEN, RISTO HEIKKI · 2011 to 2025
$23.6MRole of pattern recognition receptors in organic dust-induced airway inflammationR01ES019325 · NIEHS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI POOLE, JILL A · 2010 to 2020
$3.7MUNMC Summer Undergraduate Alcohol Research ProgramR25AA020818 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI Kristina L Bailey · 2012 to 2026
$931kAutophagy regulates airway epithelial cell mucin secretionK08HL131992 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI DICKINSON, JOHN DAVID · 2016 to 2020
$799kBLR&D Research Career Scientist AwardIK6BX003781 · VA · OMAHA VA MEDICAL CENTER · PI WYATT, TODD A · 2017 to 2021
–Improving the Management of Rheumatoid Arthritis-Associated Lung Disease in Veterans Using Real-World DataIK2CX002203 · VA · OMAHA VA MEDICAL CENTER · PI Bryant R England · 2021 to 2026
–Lung Innate COVID-19 Defense Specific to Veterans Risk CharacteristicsI01BX005413 · VA · OMAHA VA MEDICAL CENTER · PI BAILEY, KRISTINA L, WYATT, TODD A · 2021 to 2022
–BLRD VA I01 BX005413BLRD VA IK6 BX003781CSRD VA IK2 CX002203NCI NIH HHS P30 CA036727NHLBI NIH HHS K08 HL131992NIAAA NIH HHS R25 AA020818NIEHS NIH HHS R01 ES019325NIGMS NIH HHS U54 GM115458NIOSH CDC HHS U54 OH010162
Abstract
PubMed holds no abstract for this paper.
Indexed as
AdultAgedAged, 80 and overAlveolar Epithelial CellsCase-Control StudiesCOVID-19Endothelial CellsFemaleFibroblastsHumansIdiopathic Pulmonary FibrosisInterleukin-33LungMaleMiddle AgedMyocytes, Smooth MuscleIL33 protein, humanInterleukin-33Pulmonary Surfactant-Associated Protein CVimentin
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.