Evidence map›Paper›PMID 34245727›Full record

ReviewDevelopmental biology2021

Hexagonal patterning of the Drosophila eye.

Ruth I Johnson

Open access · greenAbstract readReview
In one paragraph

Review in Developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Ruth I JohnsonBiology Department, Wesleyan University, 52 Lawn Avenue, Middletown, CT, USA. Electronic address: rijohnson@wesleyan.edu.
Wesleyan University · US

Funding

The role of Cindr and its protein interactors in epithelial morphogenesisR15GM114729 · NIGMS · WESLEYAN UNIVERSITY · PI JOHNSON, RUTH INEKE · 2017 to 2022
$986k
NIGMS NIH HHS R15 GM114729
6 · The paper itself

Abstract

A complex network of transcription factor interactions propagates across the larval eye disc to establish columns of evenly-spaced R8 precursor cells, the founding cells of Drosophila ommatidia. After the recruitment of additional photoreceptors to each ommatidium, the surrounding cells are organized into their stereotypical pattern during pupal development. These support cells - comprised of pigment and cone cells - are patterned to encapsulate the photoreceptors and separate ommatidia with an hexagonal honeycomb lattice. Since the proteins and processes essential for correct eye patterning are conserved, elucidating how these function and change during Drosophila eye patterning can substantially advance our understanding of transcription factor and signaling networks, cytoskeletal structures, adhesion complexes, and the biophysical properties of complex tissues during their morphogenesis. Our understanding of many of these aspects of Drosophila eye patterning is largely descriptive. Many important questions, especially relating to the regulation and integration of cellular events, remain.

Indexed as

AnimalsBasic Helix-Loop-Helix ProteinsBody PatterningCompound Eye, ArthropodComputer SimulationDrosophilaDrosophila ProteinsErbB ReceptorsLarvaMorphogenesisNerve Tissue ProteinsPhotoreceptor Cells, InvertebratePupaReceptors, Invertebrate PeptideSignal Transductionato protein, DrosophilaBasic Helix-Loop-Helix ProteinsDrosophila ProteinsEgfr protein, DrosophilaErbB ReceptorsNerve Tissue ProteinsReceptors, Invertebrate PeptideDrosophila eyeInterommatidial cellsMorphogenesisOmmatidiaPigment cellsR8

Identifiers

PMID34245727
PMCPMC8364518
OpenAlexW3179683151

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.