Evidence map›Paper›PMID 34245621›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2021

Elucidating the structure and functions of Resolvin D6 isomers on nerve regeneration with a distinctive trigeminal transcriptome.

Thang L Pham, Azucena H Kakazu, Jiucheng He, Robert Nshimiyimana, Nicos A Petasis, Bokkyoo Jun, Nicolas G Bazan, Haydee E P Bazan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. ELV-N34, RvD6-Isomer, or NPD1 Halt Replication of SARS-CoV-2 Omicron BA.5 Virus in Human Lung and Nasal Cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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  11. Elucidating the structure and functions of Resolvin D6 isomers on nerve regeneration with a distinctive trigeminal transcriptome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Thang L PhamNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA.
Azucena H KakazuNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA.
Jiucheng HeNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA.
Robert NshimiyimanaDepartment of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, CA, USA.
Nicos A PetasisDepartment of Chemistry and Loker Hydrocarbon Research Institute, University of Southern California, Los Angeles, CA, USA.
Bokkyoo JunNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA.
Nicolas G BazanNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA.
Haydee E P BazanNeuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, New Orleans, LA, USA.
Louisiana State University Health Sciences Center New Orleans · USUniversity of Southern California · US

Funding

Lipid Mediators in Corneal Nerve RegenerationR01EY019465 · NEI · LSU HEALTH SCIENCES CENTER · PI BAZAN, HAYDEE E.P. · 2009 to 2021
$4.0M
NEI NIH HHS R01 EY019465NIH HHS R01EY019465
6 · The paper itself

Abstract

Innervation sustains cornea integrity. Pigment epithelium-derived factor (PEDF) plus docosahexaenoic acid (DHA) regenerated damaged nerves by stimulating the synthesis of a new stereoisomer of Resolvin D6 (RvD6si). Here, we resolved the structure of this lipid isolated from mouse tears after injured corneas were treated with PEDF + DHA. RvD6si synthesis was inhibited by fluvoxamine, a cytochrome P450 inhibitor, but not by 15- or 5-LOX inhibitors, suggesting that the 4- and 17-hydroxy of DHA have an RR- or SR-configuration. The two compounds were chemically synthesized. Using chiral phase HPLC, four peaks of RvD6si

Indexed as

Nerve RegenerationAnimalsDocosahexaenoic AcidsFluvoxamineHepatocyte Growth FactorMaleMiceRapamycin-Insensitive Companion of mTOR ProteinStereoisomerismStructure-Activity RelationshipTrigeminal NerveDocosahexaenoic AcidsFluvoxamineHepatocyte Growth FactorHGF protein, mouseRapamycin-Insensitive Companion of mTOR Proteinrictor protein, mousecorneal nerveshgfpainRictorRvD6 stereoisomerstrigeminal ganglia transcriptome

Identifiers

PMID34245621
PMCPMC8362171
OpenAlexW3179047403

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.