Evidence map›Paper›PMID 34245588›Full record

ReviewJournal of the American Geriatrics Society2021

Impact of dementia: Health disparities, population trends, care interventions, and economic costs.

María P Aranda, Ian N Kremer, Ladson Hinton, Julie Zissimopoulos, Rachel A Whitmer, Cynthia Huling Hummel, Laura Trejo, Chanee Fabius

Registry-linked trialAbstract readReview
In one paragraph

Review in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06741865 (Intervention Strategies for Preserving Intellectual Resilience and Engagement), which is not on this map. Cited by 221 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
221citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06741865 narecruitingnot on this mapstarted 2025, after this paper: background citation

Intervention Strategies for Preserving Intellectual Resilience and Engagement

TypeinterventionalSponsorHealthy Minds InitiativeRan2025 to 2028Enrolled2,000ConditionsDementiaArmsLifestyle Intervention, Standard Health Education
3 · Its place in the literature

Who cites it

221 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Pooled it
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  8. Is headache a risk factor for dementia? A systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  9. Pooled it
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  11. Trial
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  13. Article
  14. Article
  15. The effects of improved access to diabetes medications on risk of Alzheimer's disease and related dementias.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  16. Article
  17. Incidence and risk factors for AD/ADRD among American Indian and Alaska Native US Veterans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  18. Article
  19. Barriers and Facilitators for Implementing a Dementia Family Caregiver Support Strategy Among Latinos in Primary Care.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026
    Article
  20. Definitions of Person-Centeredness for Persons With Dementia in the United States: A Scoping Review.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2026
    Article

161 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

María P ArandaUniversity of Southern California, Los Angeles, California, USA.
Ian N KremerLEAD Coalition (Leaders Engaged on Alzheimer's Disease), Washington, District of Columbia, USA.
Ladson HintonUniversity of California, Davis, California, USA.
Julie ZissimopoulosUniversity of Southern California, Los Angeles, California, USA.
Rachel A WhitmerLEAD Coalition (Leaders Engaged on Alzheimer's Disease), Washington, District of Columbia, USA.
Cynthia Huling HummelDMin, Retired Pastor and Dementia Advocate, Elmira, New York, USA.
Laura TrejoCity of Los Angeles Department of Aging, Los Angeles, California, USA.
Chanee FabiusJohn Hopkins University, Baltimore, Maryland, USA.

Funding

Training Core (I)U54AG063546 · NIA · BROWN UNIVERSITY · PI Alexia Mary Torke · 2019 to 2026
$125.9M
VASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0M
USCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8M
The Aging Brain: Vasculature, Ischemia, and BehaviorP01AG012435 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI VINTERS, HARRY V. · 1994 to 2012
$26.4M
Epidemiology of Age-related Dementia, Mild Cognitive Impairment and Brain Pathology in a Multiethnic Cohort of Oldest-Old - Administrative SupplementRF1AG056519 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CORRADA, MARIA, WHITMER, RACHEL A · 2017 to 2020
$13.4M
Lifecourse health, cerebral pathology and ethnic disparities in dementiaRF1AG052132 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI DECARLI, CHARLES, GLYMOUR, MEDELLENA MARIA · 2016 to 2016
$13.1M
USC Resource Center for Minority Aging Research (US-RCMAR)P30AG043073 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EMMA AGUILA, JENNIFER A AILSHIRE · 2012 to 2026
$10.1M
The Johns Hopkins Alzheimer's Disease Resource Center for Minority Aging Research - Research Ed ComponentP30AG059298 · NIA · JOHNS HOPKINS UNIVERSITY · PI Joseph John Gallo, ROLAND J. THORPE · 2018 to 2026
$7.1M
Remote Data Enclave Core (RDEC)P30AG066587 · NIA · JOHNS HOPKINS UNIVERSITY · PI DANIEL E POLSKY, Jennifer L. Wolff · 2020 to 2026
$6.7M
EXPANDING MHAS RESEARCH INFRASTRUCTURE WITH HISTORICAL CLIMATE AND LIFETIME WORKPLACE ENVIRONMENTAL EXPOSURES INFLUENCING INEQUITIES IN AD/ADRDP30AG066589 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DANA P GOLDMAN, JULIE M ZISSIMOPOULOS · 2020 to 2026
$6.1M
Early Vascular Contributions to Dementia Risk in African-AmericansRF1AG050782 · NIA · UNIVERSITY OF CALIFORNIA AT DAVIS · PI WHITMER, RACHEL A · 2017 to 2017
$3.8M
Reducing Racial and Ethnic Disparities in Alzheimer's Disease: Role of ACOsR01AG055401 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZISSIMOPOULOS, JULIE M · 2017 to 2019
$2.8M
NIA NIH HHS P01 AG012435NIA NIH HHS P30 AG043073NIA NIH HHS P30 AG059298NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG066587NIA NIH HHS P30 AG066589NIA NIH HHS P50 AG005142NIA NIH HHS R01 AG055401NIA NIH HHS R13 AG063477NIA NIH HHS RF1 AG050782NIA NIH HHS RF1 AG052132NIA NIH HHS RF1 AG056519NIA NIH HHS U54 AG063546NIH HHS P30AG043073NIH HHS P30AG059298NIH HHS P30AG066530NIH HHS P30AG066587NIH HHS P30AG066589NIH HHS R01AG055401NIH HHS U54AG063546
6 · The paper itself

Abstract

introductionThe dementia experience is not a monolithic phenomenon-and while core elements of dementia are considered universal-people living with dementia experience the disorder differently. Understanding the patterning of Alzheimer's disease and related dementias (ADRD) in the population with regards to incidence, risk factors, impacts on dementia care, and economic costs associated with ADRD can provide clues to target risk and protective factors for all populations as well as addressing health disparities.

methodsWe discuss information presented at the 2020 National Research Summit on Care, Services, and Supports for Persons with Dementia and Their Caregivers, Theme 1: Impact of Dementia. In this article, we describe select population trends, care interventions, and economic impacts, health disparities and implications for future research from the perspective of our diverse panel comprised of academic stakeholders, and persons living with dementia, and care partners.

resultsDementia incidence is decreasing yet the advances in population health are uneven. Studies examining the educational, geographic and race/ethnic distribution of ADRD have identified clear disparities. Disparities in health and healthcare may be amplified by significant gaps in the evidence base for pharmacological and non-pharmacological interventions. The economic costs for persons living with dementia and the value of family care partners' time are high, and may persist into future generations.

conclusionsSignificant research gaps remain. Ensuring that ADRD healthcare services and long-term care services and supports are accessible, affordable, and effective for all segments of our population is essential for health equity. Policy-level interventions are in short supply to redress broad unmet needs and systemic sources of disparities. Whole of society challenges demand research producing whole of society solutions. The urgency, complexity, and scale merit a "whole of government" approach involving collaboration across numerous federal agencies.

Indexed as

DementiaHealth Status DisparitiesPopulation HealthAgedAged, 80 and overAlzheimer DiseaseCosts and Cost AnalysisFemaleHealthcare DisparitiesHealth Services for the AgedHumansIncidenceMaleUnited Statescare interventionsdementiadisparitieseconomic costsrace/ethnicity

Identifiers

PMID34245588
PMCPMC8608182

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.