Evidence map›Paper›PMID 34245440›Full record

ArticleMolecular neurobiology2021

Effect of m-Trifluoromethyl-diphenyl diselenide on the Pain-Depression Dyad Induced by Reserpine: Insights on Oxidative Stress, Apoptotic, and Glucocorticoid Receptor Modulation.

Cleisson Schossler Garcia, Pabliane Rodrigues Garcia, Carlos Natã da Silva Espíndola, Gustavo D'Avila Nunes, Natália Silva Jardim, Sabrina Grendene Müller, Cristiani Folharini Bortolatto, César Augusto Brüning

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular neurobiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Cleisson Schossler GarciaLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil.
Pabliane Rodrigues GarciaLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil.
Carlos Natã da Silva EspíndolaLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil.
Gustavo D'Avila NunesLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil.
Natália Silva JardimLaboratory of Synthesis, Reactivity and Pharmacological and Toxicological Evaluation of Organochalcogens, Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil.
Sabrina Grendene MüllerLaboratory of Synthesis, Reactivity and Pharmacological and Toxicological Evaluation of Organochalcogens, Federal University of Santa Maria (UFSM), Santa Maria, RS, 97105-900, Brazil.
Cristiani Folharini BortolattoLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil. cbortolatto@gmail.com.ORCID http://orcid.org/0000-0002-9509-4446
César Augusto BrüningLaboratory of Biochemistry and Molecular Neuropharmacology (LABIONEM), Postgraduate Program in Biochemistry and Bioprospecting (PPGBBio), Center for Chemical, Pharmaceutical and Food Sciences (CCQFA), Federal University of Pelotas (UFPel), Pelotas, RS, 96010-900, Brazil. cabruning@yahoo.com.br.ORCID http://orcid.org/0000-0003-0814-0203
Universidade Federal de Pelotas · BRUniversidade Federal de Santa Maria · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 420386/2018-1Conselho Nacional de Desenvolvimento Científico e Tecnológico 438384/2018-0
6 · The paper itself

Abstract

Chronic pain and depression often coexist sharing common pathological mechanisms, and available analgesics and antidepressants have demonstrated limited clinical efficacy. Evidence has demonstrated that neuronal oxidative stress, apoptosis, and also glucocorticoid receptor dysregulation facilitate the occurrence and development of both chronic pain and depression. This study evaluated the effect of the organoselenium compound m-trifluoromethyl-diphenyl diselenide [(m-CF

Indexed as

Receptors, GlucocorticoidAnimalsApoptosisChronic PainDepressionLocomotionMaleMiceOrganosilicon CompoundsOxidative StressReserpineTreatment Outcomem-trifluoromethyl-diphenyl diselenideOrganosilicon CompoundsReceptors, GlucocorticoidReserpineDepressionOrganoselenium compoundPainReserpine

Identifiers

PMID34245440
OpenAlexW3179258642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.