Evidence map›Paper›PMID 34245439›Full record

ReviewMolecular biotechnology2021

Advances in Pathophysiology of Triple-Negative Breast Cancer: The Potential of lncRNAs for Clinical Diagnosis, Treatment, and Prognostic Monitoring.

Yangkun Zhou, Yang Yue, Siyu Fan, Qiaojun Jia, Xianfeng Ding

Abstract readReview
PubMed Publisher
In one paragraph

Review in Molecular biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Subtype-Specific mInternational journal of molecular sciences · 2026
    Article
  2. Investigation of Pharmacological Mechanisms and Active Ingredients ofInternational journal of molecular sciences · 2025
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yangkun ZhouSchool of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
Yang YueSchool of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
Siyu FanSchool of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
Qiaojun JiaSchool of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China.
Xianfeng DingSchool of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou, 310018, China. Xfding@zstu.edu.cn.ORCID http://orcid.org/0000-0003-1119-3816

Funding

Zhejiang Provincial Public Benefit Technology Applied Research Project LGF21C050001
6 · The paper itself

Abstract

Recent studies have shown that long non-coding RNAs (lncRNAs) are involved in several gene expression regulation processes, including epigenetic regulation, transcriptional regulation, post-transcriptional regulation, and translation regulation. It also plays a crucial role in the regulation of several characteristics of cancer biology, and the dysregulation of lncRNA expression in cancer may be part of the cause of cancer progression. Meanwhile, more and more studies are trying to determine the association between lncRNA expression and TNBC, as well as the functional role and molecular mechanism of the abnormally expressed lncRNA. Therefore, this review lists some abnormal lncRNAs in TNBC, further analyzes their molecular mechanisms and biological roles in the development of TNBC, and summarizes the potential of lncRNAs as biomarkers and therapeutic targets of TNBC, so as to provide ideas for clinical diagnosis, targeted therapy, and prognosis monitoring of TNBC.

Indexed as

Biomarkers, TumorEarly Detection of CancerEpigenesis, GeneticGene Expression Regulation, NeoplasticHumansMolecular Targeted TherapyPrognosisRNA, Long NoncodingTriple Negative Breast NeoplasmsBiomarkers, TumorRNA, Long NoncodingBiomarkerLong non-coding RNA (lncRNA)Therapeutic targetTriple-negative breast cancer (TNBC)

Identifiers

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.