ArticleBrain structure & function2021
Simultaneous changes in visual acuity, cortical population receptive field size, visual field map size, and retinal thickness in healthy human aging.
Article in Brain structure & function, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07752433 (Combining Noninvasive Brain Stimulation and Augmented Reality-based Dichoptic Therapy for Treating Amblyopic Adults), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Combining Noninvasive Brain Stimulation and Augmented Reality-based Dichoptic Therapy for Treating Amblyopic Adults
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Visual field map size constrains working memory precision.bioRxiv : the preprint server for biology · 2026Article
- Tablet Acceptability in Older Outpatients Undergoing Cancer Chemotherapy.Geriatrics (Basel, Switzerland) · 2026Article
- Unpacking the V1 map: Differential covariation of preferred spatial frequency and cortical magnification across spatial dimensions.PLoS computational biology · 2025Article
- Article
- Influence of Anthropometric Height on Oculo-Manual Coordinative Reaction Time.Journal of functional morphology and kinesiology · 2025Article
- Cortical response to transient and long-term visual field loss.Cerebral cortex (New York, N.Y. : 1991) · 2025Article
- Improvements induced by retinal gene therapy with voretigene neparvovec depend on visual cortical hemispheric dominance mechanisms.Communications medicine · 2025Article
- Bibliometric analyses of factors influencing color preferences in urban environmental spaces.Frontiers in psychology · 2025Article
- The Role of Population Receptive Field Sizes in Higher-Order Visual Dysfunction.Current neurology and neuroscience reports · 2024Review
- Effects of voluntary and forced physical exercise on the retinal health of aging Wistar rats.GeroScience · 2024Article
- Training-induced changes in population receptive field properties in visual cortex: Impact of eccentric vision training on population receptive field properties and the crowding effect.Journal of vision · 2024Article
- Age-associated changes in electroretinography measures in companion dogs.Documenta ophthalmologica. Advances in ophthalmology · 2023Article
- Comparing retinotopic maps of children and adults reveals a late-stage change in how V1 samples the visual field.Nature communications · 2023Article
- Linking individual differences in human primary visual cortex to contrast sensitivity around the visual field.Nature communications · 2022Article
- Understanding structure-function relationships in the mammalian visual system: part one.Brain structure & function · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Healthy human aging is associated with a deterioration of visual acuity, retinal thinning, visual field map shrinkage and increasing population receptive field sizes. Here we ask how these changes are related to each other in a cross-sectional sample of fifty healthy adults aged 20-80 years. We hypothesized that age-related loss of macular retinal ganglion cells may lead to decreased visual field map sizes, and both may lead to increased pRF sizes in the cortical central visual field representation. We measured our participants' perceptual corrected visual acuity using standard ophthalmological letter charts. We then measured their early visual field map (V1, V2 and V3) functional population receptive field (pRF) sizes and structural surface areas using fMRI, and their retinal structure using high-definition optical coherence tomography. With increasing age visual acuity decreased, pRF sizes increased, visual field maps surface areas (but not whole-brain surface areas) decreased, and retinal thickness decreased. Among these measures, only functional pRF sizes predicted perceptual visual acuity, and Bayesian statistics support a null relationship between visual acuity and cortical or retinal structure. However, pRF sizes were in turn predicted by cortical structure only (visual field map surface areas), which were only predicted by retinal structure (thickness). These results suggest that simultaneous disruptions of neural structure and function throughout the early visual system may underlie the deterioration of perceptual visual acuity in healthy aging.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.