Evidence map›Paper›PMID 34245356›Full record

Trial reportClinical oral investigations2022

In vivo evaluation of whitening toothpaste efficiency and patient treatment satisfaction: a randomized controlled trial.

Nada Zorica Vladislavic, Antonija Tadin, Lidia Gavic, Daniel Jerkovic, Ivana Franic, Zeljko Verzak

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04460755 (Tooth Whitening Evaluation With Cytotoxic and Genotoxic Effect of Commercial Whitening Toothpastes on Oral Mucosal Cells), which is not on this map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04460755 naunknown statusnot on this map

Tooth Whitening Evaluation With Cytotoxic and Genotoxic Effect of Commercial Whitening Toothpastes on Oral Mucosal Cells

TypeinterventionalSponsorUniversity of ZagrebRan2019 to 2020Enrolled210ConditionsTeeth WhiteningArmsControl group, Whitening toothpaste 1, Whitening toothpaste 2, Whitening toothpaste 3, Whitening toothpaste 4
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Evaluating the Efficiency and Tooth Sensitivity of a Novel Whitening Strip: A Randomized, Double-Blind Controlled Trial.Journal of esthetic and restorative dentistry : official publication of the American Academy of Esthetic Dentistry ... [et al.] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Nada Zorica VladislavicDepartment of Dental Medicine, University Hospital Centre Zagreb, Zagreb, Croatia.ORCID http://orcid.org/0000-0001-7946-9853
Antonija TadinDepartment of Restorative Dental Medicine and Endodontics, Study of Dental Medicine, School of Medicine, University of Split, Soltanska 2, 21000, Split, Croatia. atadin@mefst.hr.ORCID http://orcid.org/0000-0002-5365-9816
Lidia GavicDepartment of Restorative Dental Medicine and Endodontics, Study of Dental Medicine, School of Medicine, University of Split, Soltanska 2, 21000, Split, Croatia.ORCID http://orcid.org/0000-0003-2882-934X
Daniel JerkovicDepartment of Maxillofacial Surgery, Clinical Hospital Centre Split, Split, Croatia.ORCID http://orcid.org/0000-0002-6431-1815
Ivana FranicDepartment of Medical Laboratory Diagnostic, University Department of Health Studies, University of Split, Split, Croatia.ORCID http://orcid.org/0000-0002-1157-1429
Zeljko VerzakDepartment of Dental Medicine, University Hospital Centre Zagreb, Zagreb, Croatia.
University Hospital Centre Zagreb · HRKlinički Bolnički Centar Split · HRUniversity of Split · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo assess the whitening efficiency and patient satisfaction after usage of commercially available toothpastes with the different whitening ingredients. MATERIALS AND

methodsThis randomized controlled trial study comprised 161 participants who were randomly divided into eight groups based on used whitening or control/conventional toothpaste (Colgate Max Expert White [CMEW], n = 20; Signal Daily White [SDW], n = 20; Himalaya Sparkly White Herbalis [HSWH], n = 20; Signal White System [SWS], n = 20; Rembrandt Deeply White + Peroxide [RDWP], n = 20; Splat Extreme White [SEW], n = 20; Splat White Plus [SWP], n = 21; and Kalodont Multi Repair [control], n = 20). Tooth color and color change were evaluated using a spectrophotometer (CIELAB coordinates, ΔE

resultsThe results for ΔL*, Δa*, and Δb* showed an increase in lightness and decrease in yellowness for all tested whitening toothpastes compared to the control group after 30 days of use (p ≤ 0.05). Also, significant tooth color difference (ΔE

conclusionsWhitening toothpastes can show perceptibly whitening effect after a short time of usage, but without a long-lasting impact. CLINICAL RELEVANCE: Toothpaste containing a combination of enzymes and peroxides showed the best whitening performance compared to those containing only enzymes, peroxides, or abrasives.

trial registrationClinicalTrials.gov: NCT04460755.

Indexed as

Tooth BleachingTooth Bleaching AgentsCarbamide PeroxideColorHumansHydrogen PeroxideToothpastesCarbamide PeroxideHydrogen PeroxideTooth Bleaching AgentsToothpastesColor measurementPatient satisfactionSide effectsTooth colorToothpasteTooth whitening

Identifiers

PMID34245356
OpenAlexW3179735495

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.