Evidence map›Paper›PMID 34245317›Full record

ArticleInternational urogynecology journal2022

Pelvic organ prolapse surgery and overactive bladder symptoms-a population-based cohort (FINPOP).

Päivi K Karjalainen, Anna-Maija Tolppanen, Nina K Mattsson, Olga A E Wihersaari, Jyrki T Jalkanen, Kari Nieminen

Abstract read
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Article in International urogynecology journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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  20. The emperor has no clothes: OAB can be cured surgically.International urogynecology journal · 2022
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Päivi K KarjalainenDepartment of Obstetrics and Gynecology, Hospital Nova of Central Finland, Hoitajantie 3, 40620, Jyväskylä, Finland. paivikristiina.karjalainen@gmail.com.ORCID http://orcid.org/0000-0002-2271-1773
Anna-Maija TolppanenSchool of Pharmacy, University of Eastern Finland, Kuopio, Finland.
Nina K MattssonInstitute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Olga A E WihersaariDepartment of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.
Jyrki T JalkanenFaculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Kari NieminenDepartment of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introduction and hypothesisIt is unclear how compartment of pelvic organ prolapse (POP) impacts overactive bladder (OAB) symptom severity or improvement after POP surgery. We hypothesized that anterior and apical prolapse are more strongly associated with OAB symptoms than posterior compartment prolapse.

methodsA total of 2933 POP surgeries from a prospective population-based cohort were divided into two groups: (1) anterior and/or apical compartment surgery (± posterior repair), N = 2091; (2) posterior repair only, N = 478. Urinary frequency and urgency urinary incontinence (UUI) were evaluated using PFDI-20 (bothersome symptom: score 3-4) at baseline, 6, and 24 months. Association between degree of POP in specific compartments and symptoms at baseline was estimated with generalized linear models and between compartment of surgery and symptom improvement with generalized estimating equations.

resultsAt least one bothersome symptom was reported by 40% at baseline, 14% at 6, and 19% at 24 months. At baseline, urinary frequency was associated with degree of anterior and apical and UUI with anterior compartment prolapse. Women undergoing surgery for anterior/apical compartment started with worse symptoms and experienced greater improvement than women undergoing posterior compartment surgery. Bothersome frequency resolved in 82% after anterior/apical and in 63% after posterior compartment surgery. Bothersome UUI resolved in 75% after anterior/apical and in 61% after posterior compartment surgery. After surgery, symptom severity was comparable between groups. Bothersome de novo symptoms occurred in 1-3%.

conclusionsOAB symptoms are more strongly related to anterior and apical than to posterior compartment prolapse, but improvement is seen after surgery for any vaginal compartment.

Indexed as

Pelvic Organ ProlapseUrinary Bladder, OveractiveUrinary IncontinenceCohort StudiesFemaleHumansProspective StudiesOveractive bladderPelvic organ prolapsePelvic organ prolapse surgeryUrgency urinary incontinenceUrinary frequency

Identifiers

PMID34245317
PMCPMC8739293

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.