Evidence map›Paper›PMID 34245175›Full record

ArticleAlcoholism, clinical and experimental research2021

Persistent attention-deficit/hyperactivity disorder predicts socially oriented, but not physical/physiologically oriented, alcohol problems in early adulthood.

Frances L Wang, Sarah L Pedersen, Traci M Kennedy, Elizabeth M Gnagy, William E Pelham, Brooke S G Molina

Open access · greenAbstract read
In one paragraph

Article in Alcoholism, clinical and experimental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Frances L WangDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-6548-0031
Sarah L PedersenDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.
Traci M KennedyDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-9865-3533
Elizabeth M GnagyDepartment of Psychology, Florida International University, Miami, FL, USA.
William E PelhamDepartment of Psychology, Florida International University, Miami, FL, USA.
Brooke S G MolinaDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA.ORCID 0000-0001-7574-3755
University of Pittsburgh · USFlorida International University · US

Funding

DEVELOPMENT OF ALCOHOL USE AND ABUSE IN ADHD ADOLESCENTSR01AA011873 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 1998 to 2007
$8.5M
The Development of Alcohol Use and Abuse in ADHD Adolescents and Young AdultsR37AA011873 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 2008 to 2017
$7.9M
INTERDISCIPLINARY ALCOHOL RESEARCH TRAINING PROGRAMT32AA007453 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BROOKE S.G. MOLINA · 1985 to 2026
$3.7M
The Pittsburgh ADHD Longitudinal Study: Predicting alcohol misuse, problems and disorder in mid-adulthoodR01AA027494 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G., PEDERSEN, SARAH L · 2020 to 2024
$2.8M
Development of Drug Use and Abuse in ADHD AdolescentsR01DA012414 · NIDA · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PELHAM, WILLIAM E · 2001 to 2012
$2.2M
The development of genetically-based pathways underlying problematic alcohol use - SupplementK01AA027757 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WANG, FRANCES L · 2020 to 2024
$908k
The Pittsburgh ADHD Longitudinal Study: Predicting alcohol misuse, problems, and disorder in mid-adulthoodR56AA011873 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 2018 to 2018
$100k
ADOLESCENT ALCOHOL ABUSE AND ATTENTION DEFICIT DISORDERK21AA000202 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MOLINA, BROOKE S.G. · 1995 to 1999
–
NIAAA NIH HHS AA000202NIAAA NIH HHS AA007453NIAAA NIH HHS AA011873NIAAA NIH HHS AA027494NIAAA NIH HHS K01 AA027757NIAAA NIH HHS K01AA027757NIAAA NIH HHS K21 AA000202NIAAA NIH HHS R01 AA011873NIAAA NIH HHS R01 AA027494NIAAA NIH HHS R37 AA011873NIAAA NIH HHS R56 AA011873NIAAA NIH HHS T32 AA007453NIDA NIH HHS DA12414NIDA NIH HHS R01 DA012414
6 · The paper itself

Abstract

backgroundAlthough individuals with histories of childhood attention-deficit/hyperactivity disorder (ADHD) report more alcohol-related problems in adulthood than those without ADHD, it is unknown whether there are group differences in certain types of alcohol problems. We tested whether the nature of alcohol problems differed for individuals with and without childhood ADHD, as well as adulthood-persistent ADHD, to facilitate a personalized medicine approach for alcohol problems in this high-risk group.

methodsData were drawn from a prospective, observational study. Children diagnosed with ADHD and demographically similar individuals without childhood ADHD were followed prospectively through young adulthood (N = 453; 87.6% male). ADHD symptom persistence was assessed using self-reports and parent reports. Alcohol problems and heavy drinking were assessed repeatedly from 18-30 years old to construct lifetime measures.

resultsFull-sample confirmatory factor analyses identified 5 alcohol problem "types:" interpersonal problems/risky behaviors, occupational/academic impairment, impaired control/treatment seeking, tolerance/withdrawal, and drinking to blackout. Latent class analyses of items within each type yielded the best fit for 3-class solutions for all sets of items except blackout drinking, for which 2 classes emerged. Children with ADHD were more likely than those without ADHD to belong to high-risk latent classes for interpersonal problems/risky behaviors, occupational/academic problems, and impaired control (the high-risk class that indexed treatment-seeking behavior). These effects were driven by individuals whose ADHD symptoms persisted into adulthood. Few group differences emerged for tolerance/withdrawal and blackout drinking, except that individuals with only childhood ADHD (no persistence) were more likely to belong to the low-risk groups than those with adulthood-persistent ADHD and without ADHD.

conclusionsIndividuals with ADHD histories whose symptoms persist into adulthood may be more likely to experience socially oriented alcohol problems and impaired control/treatment seeking than individuals without an ADHD history and those with childhood ADHD only. Tailored alcohol prevention and treatment programs may benefit this high-risk population.

Indexed as

AdolescentAdultAlcohol-Related DisordersAttention Deficit Disorder with HyperactivityChildChild, PreschoolHumansLatent Class AnalysisLongitudinal StudiesPennsylvaniaYoung AdultADHDblackout drinkingimpaired controlsocially oriented alcohol problemstolerancewithdrawal

Identifiers

PMID34245175
PMCPMC8429135
OpenAlexW3178767430

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.