ReviewAdvances in nutrition (Bethesda, Md.)2021
The Effects of Natural and Synthetic Blue Dyes on Human Health: A Review of Current Knowledge and Therapeutic Perspectives.
Review in Advances in nutrition (Bethesda, Md.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 107 citations in OpenAlex.
- Development of a crocetin-glycyrrhizic acid supramolecular composite pigment for enhancing meat color and reducing contaminant formation during heat processin.Food chemistry: X · 2026Article
- Comparative Action of Blue Food Colorants (Genipin, Patent Blue V, and Brilliant Blue FCF); Their Effect on Oxidative Stress in Human Plasma and Blood Platelets In Vitro.International journal of molecular sciences · 2026Article
- Ultrasound-responsive Janus patch with mechanical anisotropy, pro-healing, and anti-adhesion properties for abdominal wall defect repair.Journal of nanobiotechnology · 2025Article
- Optimized production and characterization of red dye from Talaromyces purpureogenus PH7 for application as a textile dye.BMC microbiology · 2025Article
- Functional Yogurt: Enhancing Color Stability, Functional Quality, and Storage Life With Malabar Spinach (Food science & nutrition · 2025Article
- Magnesium Molybdate: An Efficient Nanosorbent for Methylene Blue Cationic Dye Removal from Aqueous Solutions.Molecules (Basel, Switzerland) · 2025Article
- Genipin-Simple but Significant Bioactive Iridoid for Therapeutical Application and Beyond: A Review.Life (Basel, Switzerland) · 2025Review
- Allura Red AC is a xenobiotic. Is it also a carcinogen?Carcinogenesis · 2024Review
- Article
- Plant betalains-mixed active/intelligent films for meat freshness monitoring: A review of the fabrication parameters.Journal of food science and technology · 2024Review
- Article
- Green Synthesis, Characterization and Application of Silver Nanoparticles Using Bioflocculant: A Review.Bioengineering (Basel, Switzerland) · 2024Review
- Article
- Indigo Carmine: Between Necessity and Concern.Journal of xenobiotics · 2023Review
- Anti-Aging Potential of Plants of the Anak Dalam Tribe, Jambi, Indonesia.Pharmaceuticals (Basel, Switzerland) · 2023Review
- Optimization of Anthocyanin Production in Tobacco Cells.International journal of molecular sciences · 2023Article
- Novel Findings regarding the Bioactivity of the Natural Blue Pigment Genipin in Human Diseases.International journal of molecular sciences · 2022Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blue synthetic dyes are widely used in many industries. Although they are approved for use as food dyes and in cosmetics and some medicines, their impacts on consumer health remain unknown. Some studies indicate that 2 synthetic dyes, Blue No. 1 and Blue No. 2, may have toxic effects. It has therefore been suggested that these should be replaced with natural dyes; however, despite being nontoxic and arguably healthier than synthetic dyes, these compounds are often unsuitable for use in food or drugs due to their instability. Nevertheless, among the natural blue pigments, anthocyanins and genipin offer particular health benefits, as they are associated with the prevention of cardiovascular disease and have anticancer, neuroprotective, anti-inflammatory, and antidiabetic properties. This review summarizes the effects of blue food and drug colorings on health and proposes that synthetic colors should be replaced with natural ones.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.