Evidence map›Paper›PMID 34245014›Full record

ArticleThe Journal of comparative neurology2021

Characterization of Tbr2-expressing retinal ganglion cells.

Ching-Kang Chen, Takae Kiyama, Nicole Weber, Christopher M Whitaker, Ping Pan, Tudor C Badea, Stephen C Massey, Chai-An Mao

Open access · greenAbstract read
In one paragraph

Article in The Journal of comparative neurology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 20 citations in OpenAlex.

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  10. Frontiers in cell and developmental biology · 2025
    Review
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  12. A newbioRxiv : the preprint server for biology · 2024
    Article
  13. The RBPMSiScience · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ching-Kang ChenDepartment of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA.
Takae KiyamaRuiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.
Nicole WeberDepartment of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA.
Christopher M WhitakerRuiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.
Ping PanRuiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.
Tudor C BadeaNational Eye Institute, National Institutes of Health, Bethesda, Maryland, USA.ORCID 0000-0003-3086-6713
Stephen C MasseyRuiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.
Chai-An MaoRuiz Department of Ophthalmology and Visual Science, McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Houston, Texas, USA.ORCID 0000-0002-9700-6964
The University of Texas Health Science Center · USBaylor College of Medicine · USThe University of Texas MD Anderson Cancer Center · USNational Institutes of Health · US

Funding

Retinal Circuit Development & GeneticsZIAEY000504 · NEI · NATIONAL EYE INSTITUTE · PI BADEA, TUDOR · 2011 to 2021
$15.6M
VISION RESEARCH CENTERP30EY002520 · NEI · BAYLOR COLLEGE OF MEDICINE · PI Samuel M Wu · 1985 to 2026
$14.8M
NEUROTRANSMITTER MECHANISMS IN THE RETINAR01EY006515 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MASSEY, STEPHEN C · 1985 to 2017
$7.0M
The role of T-box transcriptional regulator Tbr2 in the development of ipRGCsR01EY024376 · NEI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI MAO, CHAI-AN · 2015 to 2024
$3.9M
UTHouston Core Center for Vision ResearchP30EY028102 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DRAGOI, VALENTIN · 2017 to 2021
$3.1M
Rod/cone gap junctions initiate an irradiance pathwayR01EY029408 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MASSEY, STEPHEN C, RIBELAYGA, CHRISTOPHE P. · 2018 to 2022
$2.9M
Mechanisms, functions and utility of RGC oscillation in retinal deafferentation mouse modelsR01EY026930 · NEI · BAYLOR COLLEGE OF MEDICINE · PI CHEN, CHING-KANG JASON, WU, SAMUEL M · 2017 to 2019
$1.2M
The Synaptic Mechanism of Direction Selectivity in the RetinaF32EY021958 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI WHITAKER, CHRISTOPHER MICHAEL · 2011 to 2013
$155k
NEUROTRANSMITTER MECHANISMS IN THE RETINAR55EY006515 · NEI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MASSEY, STEPHEN C. · 1991 to 1991
–
NEI NIH HHS EY006515NEI NIH HHS EY021958NEI NIH HHS EY024376NEI NIH HHS EY026930NEI NIH HHS F32 EY021958NEI NIH HHS P30 EY002520NEI NIH HHS P30EY002520NEI NIH HHS P30 EY028102NEI NIH HHS P30EY028102NEI NIH HHS R01 EY006515NEI NIH HHS R01 EY024376NEI NIH HHS R01 EY026930NEI NIH HHS R01 EY029408
6 · The paper itself

Abstract

The mammalian retina contains more than 40 retinal ganglion cell (RGC) subtypes based on their unique morphologies, functions, and molecular profiles. Among them, intrinsically photosensitive RGCs (ipRGCs) are the first specified RGC type emerging from a common retinal progenitor pool during development. Previous work has shown that T-box transcription factor T-brain 2 (Tbr2) is essential for the formation and maintenance of ipRGCs, and that Tbr2-expressing RGCs activate Opn4 expression upon native ipRGC ablation, suggesting that Tbr2

Indexed as

AnimalsDendritesFemaleGene ExpressionMaleMiceMice, 129 StrainMice, Inbred C57BLMice, TransgenicRetinal Ganglion CellsT-Box Domain ProteinsEomes protein, mouseT-Box Domain Proteinsdisplaced amacrine cellsintrinsically photosensitive retinal ganglion cellsOpn4Tbr2

Identifiers

PMID34245014
PMCPMC8349894
OpenAlexW3183111615

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.